Exercise-induced hypothalamic neuroplasticity: Implications for energy and glucose metabolism.
Exercise-induced hypothalamic neuroplasticity: Implications for energy and glucose metabolism.
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DOI：
10.1016/j.molmet.2023.101745
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发表时间：
2023-07
影响因子：
8.1
通讯作者：
Williams, Kevin W.
中科院分区：
文献类型：
--
作者：
Hwang, Eunsang;Portillo, Bryan;Grose, Kyle;Fujikawa, Teppei;Williams, Kevin W.
神经可塑性是指大脑因应对不同挑战而发生功能和结构变化的能力。越来越多的证据支持这样的观点：运动是一种代谢挑战，会触发外周和大脑内多种因子的释放。这些因素积极促进大脑的可塑性，进而调节能量和葡萄糖代谢。本综述的主要重点是探讨运动引起的大脑可塑性对代谢稳态的影响，重点是下丘脑在此过程中的作用。此外，该综述还概述了运动引起的有助于能量平衡和葡萄糖代谢的各种因素。值得注意的是，这些因素至少部分地通过下丘脑内以及更广泛的中枢神经系统内的作用发挥作用。运动会引起新陈代谢的短暂和持续变化，并伴随特定大脑区域内神经活动的变化。重要的是，运动引起的可塑性的贡献以及神经可塑性影响运动效果的潜在机制尚不清楚。最近的工作已经开始通过检查运动诱发因素的复杂相互作用来克服这一知识空白，这些因素会改变神经回路特性以影响新陈代谢。
Neuroplasticity refers to the brain's ability to undergo functional and structural changes in response to diverse challenges. Converging evidence supports the notion that exercise serves as a metabolic challenge, triggering the release of multiple factors both in the periphery and within the brain. These factors actively contribute to plasticity in the brain, and in turn, regulate energy and glucose metabolism. The primary focus of this review is to explore the impact of exercise-induced plasticity in the brain on metabolic homeostasis, with an emphasis on the role of the hypothalamus in this process. Additionally, the review provides an overview of various factors induced by exercise that contribute to energy balance and glucose metabolism. Notably, these factors exert their effects, at least in part, through actions within the hypothalamus and more broadly in the central nervous system. Exercise elicits both transient and sustained changes in metabolism, accompanied by changes in neural activity within specific brain regions. Importantly, the contribution of exercise-induced plasticity and the underlying mechanisms by which neuroplasticity influences the effects of exercise are not well understood. Recent work has begun to overcome this gap in knowledge by examining the complex interactions of exercise-induced factors which alter neural circuit properties to influence metabolism.
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影响因子：
3.5
作者：
Anderson EJ;Çakir I;Carrington SJ;Cone RD;Ghamari-Langroudi M;Gillyard T;Gimenez LE;Litt MJ
通讯作者：
Litt MJ
影响因子：
8.2
作者：
Alonge KM;D'Alessio DA;Schwartz MW
通讯作者：
Schwartz MW
影响因子：
9.3
作者：
Bobbo VC;Engel DF;Jara CP;Mendes NF;Haddad-Tovolli R;Prado TP;Sidarta-Oliveira D;Morari J;Velloso LA;Araujo EP
通讯作者：
Araujo EP
影响因子：
9.8
作者：
Cairns, SP
通讯作者：
Cairns, SP
影响因子：
3.3
作者：
Cao, WH;Fan, W;Morrison, SF
通讯作者：
Morrison, SF