Causes of death among people with convulsive epilepsy in rural West China A prospective study
Causes of death among people with convulsive epilepsy in rural West China A prospective study
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DOI：
10.1212/wnl.0b013e318223c784
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发表时间：
2011-07-01
期刊：
影响因子：
9.9
通讯作者：
Zhou, D.
中科院分区：
文献类型：
--
作者：
Mu, J.;Liu, L.;Zhou, D.
背景：癫痫是一种严重的健康问题，与过早死亡的风险增加有关。很少有研究调查这种情况的风险因素。了解这些风险可能使预防措施的实施，以减少过早mortals.Methods：惊厥形式的癫痫的管理程序已经到位，自2005年5月以来，在中国西部农村的初级卫生保健水平。从该方案开始到2009年12月底，参加者的人口统计数据和推定死亡原因已经记录在案。根据2007年中国农村人口资料，估算了病死率（CF）、各死因的比例死亡率（PMR）、各年龄段和各死因的标准化死亡率（SMR）。在中位28个月的随访期间，CF为2.97%。PMR最高的是意外死亡（59%），包括溺水（45.1%）;可能的癫痫猝死（SUDEP）（14.7%）;癫痫持续状态（6.9%）和肿瘤（6.9%）。总体SMR为4.92（95%置信区间4.0-6.1）;年轻人的风险较高。溺水的风险是82倍，比一般population.Conclusion：在中国西部农村，过早死亡的风险是近5倍，惊厥性癫痫患者比一般中国人群，尤其是年轻人。意外死亡（包括溺水）和可能的SUDEP是中国西部农村惊厥性癫痫患者的主要死因。神经病学（R）2011;77：132-137
Background: Epilepsy is a serious health problem associated with an increased risk of premature mortality. Few studies have investigated risk factors for this. Understanding these risks may enable the implementation of preventative measures to reduce premature mortality.Methods: A management program for convulsive forms of epilepsy has been in place at the primary health care level in rural West China since May 2005. Demographic data and putative causes of death of attendees of the program since inception to the end of December 2009 have been recorded. Case fatality (CF), the proportional mortality ratios (PMRs) for each cause, and standardized mortality ratios (SMRs) for each age and cause were estimated based on the 2007 Chinese rural population.Results: There were 106 reported deaths (70 male) among 3,568 people. CF was 2.97% during a median of 28 months' follow-up. The highest PMRs were for accidental death (59%) including drowning (45.1%); probable sudden unexpected death in epilepsy (SUDEP) (14.7%); status epilepticus (6.9%), and neoplasm (6.9%). The overall SMR was 4.92 (95% confidence interval 4.0-6.1); the risks were high in young people. The risk of drowning was 82-fold higher in the cohort than the general population.Conclusion: In rural West China, the risk of premature death is nearly 5 times higher in people with convulsive epilepsy than in the general Chinese population and especially high among young people. Accidental death, including drowning, and probable SUDEP are the leading putative causes of death in people with convulsive epilepsy in rural West China. Neurology(R) 2011;77:132-137