LanA (Language Atlas): A probabilistic atlas for the language network based on fMRI data from >800 individuals

LanA (Language Atlas): A probabilistic atlas for the language network based on fMRI data from >800 individuals
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LanA(语言图谱):基于超过 800 人的 fMRI 数据的语言网络概率图谱

DOI:
10.1101/2022.03.06.483177
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发表时间:
2022
期刊:
bioRxiv
影响因子:
--
通讯作者:
Evelina Fedorenko
Evelina Fedorenko
中科院分区:
--
文献类型:
--
作者:
Benjamin Lipkin;Greta Tuckute;Josef Affourtit;Hannah Small;Zachary Mineroff;Hope H. Kean;Olessia Jouravlev;L. Rakocevic;Brianna Pritchett;Matthew Siegelman;Caitlyn Hoeflin;Alvince L. Pongos;I. Blank;Melissa Kline Struhl;Anna A. Ivanova;S. Shannon;Aalok Sathe;Malte Hoffmann;Alfonso Nieto;Evelina Fedorenko

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FMRI语言研究有两个分析传统。一种依赖于对个体体素激活的平均。这种方法有局限性:由于语言区域位置的个体间差异,共同大脑空间中的位置不能与功能有意义地联系起来。另一种方法依赖于使用一个功能性的“本地化程序”来识别每个人的语言区域。由于其更高的敏感性、功能分辨率和可解释性,功能定位越来越受欢迎,但它并不总是可行的,也不能追溯到过去的研究中。我们提供了一种解决方案,以概率功能图谱的形式弥合这些目前不相交的方法,该图谱是从806个人的广泛验证的语言本地化的fMRI数据中创建的。这一图谱能够估计共同大脑空间中任何给定位置属于语言网络的概率,因此可以帮助解释组级峰值和此类峰值的荟萃分析,以及患者调查中的病变位置。对不同研究的结果进行更有意义的比较应该会增加语言研究的稳健性和可复制性。
Two analytic traditions characterize fMRI language research. One relies on averaging activations voxel-wise across individuals. This approach has limitations: because of inter-individual variability in the locations of language areas, a location in a common brain space cannot be meaningfully linked to function. An alternative approach relies on identifying language areas in each individual using a functional ‘localizer’. Because of its greater sensitivity, functional resolution, and interpretability, functional localization is gaining popularity, but it is not always feasible, and cannot be applied retroactively to past studies. We provide a solution for bridging these currently disjoint approaches in the form of a probabilistic functional atlas created from fMRI data for an extensively validated language localizer in 806 individuals. This atlas enables estimating the probability that any given location in a common brain space belongs to the language network, and thus can help interpret group-level peaks and meta-analyses of such peaks, and lesion locations in patient investigations. More meaningful comparisons of findings across studies should increase robustness and replicability in language research.
DOI: 10.1101/2021.09.18.460917
发表时间: 2021-01
期刊: The Journal of Neuroscience
影响因子: --
作者:
Cory Shain;I. Blank;Evelina Fedorenko;E. Gibson;William Schuler
通讯作者: Cory Shain;I. Blank;Evelina Fedorenko;E. Gibson;William Schuler
DOI: --
发表时间: 2011
期刊: --
影响因子: --
作者:
Evelina Fedorenko;Alfonso Nieto-Castanon;N. Kanwisher
通讯作者: Evelina Fedorenko;Alfonso Nieto-Castanon;N. Kanwisher
DOI: 10.1152/jn.00032.2010
发表时间: 2010-08-01
影响因子: 2.5
作者:
Fedorenko, Evelina;Hsieh, Po-Jang;Kanwisher, Nancy
通讯作者: Kanwisher, Nancy
DOI: 10.1152/jn.00884.2013
发表时间: 2014-09-01
影响因子: 2.5
作者:
Blank, Idan;Kanwisher, Nancy;Fedorenko, Evelina
通讯作者: Fedorenko, Evelina