FUNCTIONAL AND STRUCTURAL-CHANGES IN THE RABBIT EAR ARTERY AFTER SYMPATHETIC DENERVATION
FUNCTIONAL AND STRUCTURAL-CHANGES IN THE RABBIT EAR ARTERY AFTER SYMPATHETIC DENERVATION
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DOI：
10.1161/01.res.49.2.478
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发表时间：
1981-01-01
影响因子：
20.1
通讯作者：
TSURU, H
中科院分区：
文献类型：
--
作者：
BEVAN, RD;TSURU, H
研究了白新西兰兔耳中央动脉去神经节段和神经节段的组织重量、尺寸、收缩性、弹性和外源性去甲肾上腺素的敏感性。三个不同年龄组接受单侧颈上神经节切除术，3-4周生长，9-11周青壮年，16-20周成熟。在生长组，神经节切除术后8周，与对侧对照血管相比，去神经支配动脉的组织重量（11%）、总壁厚（12%）、介质横截面积（17%）、收缩力（16%）平均下降，切向弹性模量和对NE的敏感性（2.3倍）增加。内侧横截面积的变化在生长期和青壮年有显著性意义，而在成熟期没有。其他的变化，虽然一直可见，但在数量上在各组之间有所不同。显然，完整的神经支配对于动脉壁的正常发育和维持是必要的。这种影响的确切后果在不同的年龄有所不同。这种影响是否涉及一种特殊的热带因素尚不清楚。
The tissue weight, dimensions, contractility, elasticity and sensitivity to exogenous norepinephrine (NE) of denervated and innervated segments of the central ear arteries of white New Zealand rabbits was studied. Three different age groups received unilateral superior cervical ganglionectomies, growing at 3-4 wk, young adult at 9-11 wk and mature at 16-20 wk. In the growing group, 8 wk after ganglionectomy, the denervated arteries showed mean decreases in tissue weight (11%), total wall thickness (12%), cross-sectional area of media (17%), contractility (16%) and increases in the tangential modulus of elasticity and sensitivity to NE (2.3-fold) compared to the contralateral control vessels. The change in medial cross-sectional area was significant in the growing and young adult but not the mature animals. The other changes, although consistently seen, differed quantitatively among the groups. Evidently an intact innervation is necessary for normal development and maintenance of the artery wall. The precise consequences of this influence vary at different ages. Whether this influence involves a special tropic factor is not known.