Deposition behavior of inhaled nanostructured TiO2 in rats: fractions of particle diameter below 100 nm (nanoscale) and the slicing bias of transmission electron microscopy
Deposition behavior of inhaled nanostructured TiO2 in rats: fractions of particle diameter below 100 nm (nanoscale) and the slicing bias of transmission electron microscopy
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DOI：
10.3109/08958378.2012.738256
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发表时间：
2012-12-01
影响因子：
2.1
通讯作者：
Landsiedel, Robert
中科院分区：
文献类型：
--
作者：
Morfeld, Peter;Treumann, Silke;Landsiedel, Robert
Context: In experimental studies with nanomaterials where translocation to secondary organs was observed, the particle sizes were smaller than 20 nm and were mostly produced by spark generators. Engineered nanostructured materials form microsize aggregates/agglomerates. Thus, it is unclear whether primary nanoparticles or their small aggregates/agglomerates occur in non-negligible concentrations after exposure to real-world materials in the lung.Objective: We dedicated an inhalation study with nanostructured TiO2 to the following research question: Does the particle size distribution in the lung contain a relevant subdistribution of nanoparticles?Methods: Six rats were exposed to 88 mg/m(3) TiO2 over 5 days with 20% (count fraction) and
