THE MACROLACTINS, A NOVEL CLASS OF ANTIVIRAL AND CYTO-TOXIC MACROLIDES FROM A DEEP-SEA MARINE BACTERIUM
THE MACROLACTINS, A NOVEL CLASS OF ANTIVIRAL AND CYTO-TOXIC MACROLIDES FROM A DEEP-SEA MARINE BACTERIUM
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DOI：
10.1021/ja00201a036
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发表时间：
1989-09-13
影响因子：
15
通讯作者：
FENICAL, W
中科院分区：
文献类型：
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作者：
GUSTAFSON, K;ROMAN, M;FENICAL, W
八个新的次级代谢产物，macrolactins A-F（1-6）和macrolactinic和isomacrolactinic酸（7和8），一个前所未有的C24线性acetogenin的来源，已被分离从一个显然无法分类的海洋细菌的培养液。新化合物包括24元环内酯和相关的葡萄糖β-吡喃糖苷和开链酸。Macrolactin A（1）是母体糖苷配基，在体外试验中显示出选择性抗菌活性并抑制B16-F10鼠黑素瘤癌细胞。巨乳素A还显示出对哺乳动物单纯疱疹病毒（I型和II型）的显著抑制作用，并保护T淋巴母细胞免受人类HIV病毒复制。
Eight new secondary metabolites, macrolactins A-F (1-6) and macrolactinic and isomacrolactinic acids (7 and 8), of an unprecedented C24 linear acetogenin origin, have been isolated from the culture broth of an apparently taxonomically unclassifiable marine bacterium. The new compounds include 24-membered ring lactones and related glucose .beta.-pyranosides and open-chain acids. Macrolactin A (1), the parent aglycon, shows selective antibacterial activity and inhibits B16-F10 murine melanoma cancer cells in vitro assays. Macrolactin A also shows significant inhibition of mammalian Herpes simplex viruses (types I and II) and protects T-lymphoblast cells against human HIV viral replication.