Nutrition and Lung Growth.

Nutrition and Lung Growth.
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DOI:
10.3390/nu10070919
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发表时间:
2018-07-18
期刊:
影响因子:
5.9
通讯作者:
Cogo P
Cogo P
中科院分区:
医学2区
文献类型:
--
作者:
Arigliani M;Spinelli AM;Liguoro I;Cogo P

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来自动物模型和流行病学研究的实验证据表明,营养影响肺发育,并可能对呼吸健康产生终生影响。怀孕期间长期限制营养和/或氧气会导致呼吸道和实质的结构变化,可能导致肺功能异常,这在一生中都会被跟踪。早产儿不适当的营养管理阻碍了肺的生长,可能是导致支气管肺发育不良的一个因素。最近的证据似乎表明,婴儿和儿童营养不良并不能确定肺功能受损,即使肺大小因身体发育迟缓而缩小。这篇综述将集中在关键时期的营养不良,如怀孕、早期生活和儿童时期,对肺生长和长期肺功能的影响。
Experimental evidence from animal models and epidemiology studies has demonstrated that nutrition affects lung development and may have a lifelong impact on respiratory health. Chronic restriction of nutrients and/or oxygen during pregnancy causes structural changes in the airways and parenchyma that may result in abnormal lung function, which is tracked throughout life. Inadequate nutritional management in very premature infants hampers lung growth and may be a contributing factor in the pathogenesis of bronchopulmonary dysplasia. Recent evidence seems to indicate that infant and childhood malnutrition does not determine lung function impairment even in the presence of reduced lung size due to delayed body growth. This review will focus on the effects of malnutrition occurring at critical time periods such as pregnancy, early life, and childhood, on lung growth and long-term lung function.
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