Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.
Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.
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DOI：
10.1084/jem.169.1.345
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发表时间：
1989-01-01
期刊：
影响因子：
--
通讯作者：
Thorsby E
中科院分区：
文献类型：
--
作者：
Sollid LM;Markussen G;Ek J;Gjerde H;Vartdal F;Thorsby E
用HLA-DQA 1和-DQB 1等位基因特异性寡核苷酸探针对94名患有乳糜泻（CD）的无关儿童进行DNA分型，结果显示，除一名（即，98.9%）可能共享DQA 1和DQB 1基因的特定组合。这些基因在DR 3DQw 2单倍型上排列在顺式位置，在DR 5DQw 7/DR 7 DQw 2杂合子个体中排列在反式位置。因此，大多数CD患者可共享相同的顺式或反式编码的HLA-DQ α/β异二聚体。
Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans- encoded HLA-DQ alpha/beta heterodimer.