Predictors of Macular Atrophy Detected by Fundus Autofluorescence in Patients With Neovascular Age-Related Macular Degeneration After Long-Term Ranibizumab Treatment
Predictors of Macular Atrophy Detected by Fundus Autofluorescence in Patients With Neovascular Age-Related Macular Degeneration After Long-Term Ranibizumab Treatment
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DOI：
10.3928/23258160-20160229-04
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发表时间：
2016-03-01
影响因子：
1
通讯作者：
Sadda, SriniVas R.
中科院分区：
文献类型：
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作者：
Kuehlewein, Laura;Dustin, Laurie;Sadda, SriniVas R.
背景与目的：研究接受雷珠单抗治疗的新生血管性年龄相关性黄斑变性（AMD）患者脉络膜新生血管（CNV）病变的基线形态学特征与黄斑萎缩的长期发展之间的关系（Lucentis; Genentech，South San弗朗西斯科，CA）。经认证的分级员评估了来自MARINA/锚和HORIZON试验的41只眼睛的基线和7年随访（SEVEN-UP研究）图像。使用GRADOR软件和逐步线性回归，分级者将两次访视时荧光素血管造影（FA）上的病变特征与SEVEN-UP访视时眼底自体荧光（FAF）成像上的明确自体荧光减少（DAF）区域相关联。（7.3%）在基线时FA显示黄斑萎缩（平均值±标准差[SD]尺寸：0.29 mm（2）± 1.50 mm（2）），29（70.7%）（平均值±标准差[SD]面积：7.42 mm（2）± 7.97 mm（2））。在SEVEN-UP访视时的FAF成像中，所有41只眼睛（100%）均存在DAF（平均值+/- SD尺寸：10.29 mm（2）+/- 8.07 mm（2））。与SEVEN-UP访视时的扩张面积显著相关的变量是CNV病变成分渗漏的面积（系数：0.953; P
BACKGROUND AND OBJECTIVE: To study the relationship between baseline morphologic characteristics of the choroidal neovascular (CNV) lesion and long-term development of macular atrophy in eyes with neovascular age-related macular degeneration (AMD) treated with ranibizumab (Lucentis; Genentech, South San Francisco, CA).PATIENTS AND METHODS: Certified graders evaluated baseline and 7-year follow-up (SEVEN-UP study) images of 41 eyes from the MARINA/ANCHOR and HORIZON trials. Using GRADOR software and stepwise linear regression, graders correlated lesion characteristics on fluorescein angiography (FA) at both visits with areas of definite decreased autofluorescence (DDAF) on fundus autofluorescence (FAF) imaging at the SEVEN-UP visit.RESULTS: Three of 41 eyes (7.3%) had macular atrophy on FA at baseline (mean +/- standard deviation [SD] size: 0.29 mm(2) +/- 1.50 mm(2)), 29 (70.7%) at SEVEN-UP (mean +/- standard deviation [SD] area: 7.42 mm(2) +/- 7.97 mm(2)). On FAF imaging at the SEVEN-UP visit, all 41 eyes (100%) had DDAF (mean +/- SD size: 10.29 mm(2) +/- 8.07 mm(2)). Variables significantly associated with area of DDAF at the SEVEN-UP visit were the area of leaking CNV lesion components (coefficient: 0.953; P