EFFECTS OF ACCELERATED FRACTIONATION ON RADIATION-INJURY OF THE SMALL-INTESTINE - A NEW RAT MODEL
EFFECTS OF ACCELERATED FRACTIONATION ON RADIATION-INJURY OF THE SMALL-INTESTINE - A NEW RAT MODEL
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DOI：
10.1016/0360-3016(88)90399-9
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发表时间：
1988-06-01
影响因子：
7
通讯作者：
OSBORNE, JW
中科院分区：
文献类型：
--
作者：
HAUERJENSEN, M;POULAKOS, L;OSBORNE, JW
本研究评估了缩短总治疗时间（加速分割）对小肠放射损伤的影响。建立了大鼠小肠局部重复照射模型。将年轻成年雄性Sprague-Dawley大鼠睾丸切除，并将远端回肠的环移位到阴囊的左侧部分。肠段用56戈伊的总剂量照射，分20次给药，总治疗时间为26、12或7天（即每天1、2或3次）。在末次照射后6小时和2周通过组织病理学检查评估放射损伤。手术过程没有并发症。通过每天给予一次以上的放射剂量来缩短总治疗时间，导致在6小时和2周时损伤显著增加。它的结论是，加速分馏结果增加辐射损伤的肠相比，标准的分馏。由于肠道的早期和晚期效应之间可能存在关系，我们的研究结果还表明，晚期放射性肠病的增加可能是由于加速分馏。
The present study assessed the influence of shortening the overall treatment time (accelerated fractionation) on radiation injury of the small intestine. A rat model which allowed repeated irradiation of a localized segment of small intestine was developed. Young adult male Sprague-Dawley rats were orchiectomized, and a loop of the distal ileum was transposed to the left part of the scrotum. The intestinal segment was irradiated with a total dose of 56 Gy, given in 20 fractions, the total treatment time being either 26, 12, or 7 days (i.e. 1, 2, or 3 fractions per day). Radiation injury was assessed by histopathologic examination at 6 hr and at 2 weeks after the last irradiation. The surgical procedure was without complications. Shortening the overall treatment time by giving more than one radiation dose per day resulted in markedly increased injury both at 6 hr and at 2 weeks. It is concluded that accelerated fractionation results in increased radiation injury of the intestine when compared with standard fractionation. Because there may be a relationship between early and late effects in the intestine, our results also indicate that increased late radiation enteropathy may result from accelerated fractionation.