Effects of porcine gastrin releasing peptide (GRP) on canine antral motility and gastrin release in vivo.
Effects of porcine gastrin releasing peptide (GRP) on canine antral motility and gastrin release in vivo.
复制标题
猪胃泌素释放肽（GRP）对犬胃窦运动和体内胃泌素释放的影响。
DOI：
10.1016/0024-3205(84)90400-4
复制
发表时间：
1984
期刊：
影响因子：
6.1
通讯作者：
J. Fox
中科院分区：
文献类型：
--
作者：
T. McDonald;J. Fox
研究了GRP对犬体内胃窦的影响。GRP引起胃窦胃泌素分泌量呈剂量依赖性增加，而河豚毒素没有显著改变胃窦胃泌素分泌量。高剂量的GRP也引起了心房运动的兴奋，而这种兴奋被河豚毒素所消除，这一发现与先前的体外实验结果相反，结果表明bombesin诱导的心房平滑肌收缩是抗河豚毒素的。这些数据表明，在犬体内模型中，GRP通过非规则介导的机制（可能直接作用于g细胞）引起胃窦胃泌素释放，并通过神经介导的机制激发胃窦运动。
The effect of GRP on the vivo canine antrum was investigated. GRP caused a dose-dependent increase in antral gastrin output which was not significantly altered by administration of tetrodotoxin. The higher doses of GRP administered also caused excitation of antral motility which was abolished by tetrodotoxin, a finding in contrast to previous in vitro results demonstrating bombesin-induced antral smooth muscle contraction to be tetrodotoxin-resistant. These data suggest that in the vivo canine model GRP causes antral gastrin release via non-reurally mediated mechanisms (probably by acting directly on the G-cell) and excites antral motility via neurally-mediated mechanisms.
离体灌注大鼠胃胃泌素和生长抑素分泌的差异调节。
影响因子：
29.4
作者：
Martindale,R;Kauffman,GL;Levin,S;Walsh,JH;Yamada,T
通讯作者：
Yamada,T
影响因子：
2.9
作者：
Koch,TR;Otterson,MF;Roddy,DR;Go,VL
通讯作者：
Go,VL