Chemokines as modulators of neuroendocrine functions.
Chemokines as modulators of neuroendocrine functions.
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DOI：
10.1677/jme-07-0006
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发表时间：
2007-03
影响因子：
3.5
通讯作者：
W. Rostène;J. Buckingham
中科院分区：
文献类型：
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作者：
W. Rostène;J. Buckingham
趋化因子是一种分泌的小蛋白，对免疫细胞具有趋化作用。除了在免疫系统中发挥作用外，趋化因子及其受体在中枢神经系统中也可能发挥重要作用。涉及神经炎症的神经退行性疾病，如多发性硬化症、中风、阿尔茨海默病、帕金森氏病和艾滋病毒相关性痴呆，通常与局部上调和趋化因子的释放有关。然而，最近的研究已经证实，某些化学因子在大脑中结构性表达，在大脑中发挥不同于炎症的功能。这些趋化因子在大脑发育过程中调节神经元的迁移，调节神经元的活动，并在各种神经退行性疾病、疼痛以及最近的神经内分泌功能中发挥作用。2006年6月，在美国宾夕法尼亚州匹兹堡举行的第六届国际神经内分泌学大会上，该领域的先驱们提出了这些新的方面，主要集中在趋化因子基质细胞衍生因子-1/CXCL12及其受体CXCR4。
Chemokines are small secreted proteins with chemoattractant properties for immune cells. Besides their role in the immune system, chemokines and their receptors may play important roles in the central nervous system. Neurodegenerative disorders that involve neuroinflammation such as multiple sclerosis, stroke, Alzheimer's disease, Parkinson's disease and HIV-associated dementia are commonly associated with local upregulation and release of chemokines. However, recent work has established that certain chemokines, constitutively expressed in the brain, exert functions in the brain that are distinct from inflammation. These chemokines regulate neuronal migration during brain development, modulate neuronal activity and play a role in various neurodegenerative diseases, pain and more recently in neuroendocrine functions. All these novel aspects, mainly focused on the chemokine stromal cell-derived factor-1/CXCL12 and its receptor CXCR4, were presented by pioneers in the field during the symposium held at the sixth International Congress of Neuroendocrinology in Pittsburgh, Pennsylvania, USA in June 2006.