Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles
Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles
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DOI：
10.1016/j.cell.2013.04.029
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发表时间：
2013-05-23
期刊：
影响因子：
64.5
通讯作者：
Cowman, Alan F.
中科院分区：
文献类型：
--
作者：
Regev-Rudzki, Neta;Wilson, Danny W.;Cowman, Alan F.
细胞间通讯是一种重要的信息交换机制，促进细胞存活，以控制细胞群密度和分化等特征。我们确定，恶性疟原虫感染的红细胞直接交流寄生虫之间的人口使用外泌体样囊泡，能够提供基因。重要的是，通过外泌体样囊泡的通信以一定的速度促进了性形式的分化，这表明信号传导参与其中。此外，我们已经确定了一种恶性疟原虫蛋白PfPTP 2，它在有效的通信中起着关键作用。这项研究揭示了一种以前未被发现的恶性疟原虫生物学途径，该途径对于在宿主中生存和传播给蚊子至关重要。这确定了开发阻断寄生虫从人类宿主传播到蚊子的药剂的途径。
Cell-cell communication is an important mechanism for information exchange promoting cell survival for the control of features such as population density and differentiation. We determined that Plasmodium falciparum-infected red blood cells directly communicate between parasites within a population using exosome-like vesicles that are capable of delivering genes. Importantly, communication via exosome-like vesicles promotes differentiation to sexual forms at a rate that suggests that signaling is involved. Furthermore, we have identified a P. falciparum protein, PfPTP2, that plays a key role in efficient communication. This study reveals a previously unidentified pathway of P. falciparum biology critical for survival in the host and transmission to mosquitoes. This identifies a pathway for the development of agents to block parasite transmission from the human host to the mosquito.