Expression of viral MicroRNAs in Epstein-Barr virus-associated gastric carcinoma
Expression of viral MicroRNAs in Epstein-Barr virus-associated gastric carcinoma
复制标题
DOI：
10.1128/jvi.02271-06
复制
发表时间：
2007-01-01
影响因子：
5.4
通讯作者：
Lee, Suk Kyeong
中科院分区：
文献类型：
--
作者：
Kim, Do Nyun;Chae, Hiun-Suk;Lee, Suk Kyeong
EB病毒（EBV）与全球约6%至16%的胃癌病例相关。在EBV感染的B细胞和鼻咽癌细胞中观察到EBV microRNA（miRNAs）的表达。然而，目前尚不清楚EBV miRNA是否在EBV相关胃癌（EBVaGC）中表达。我们发现BART miRNAs在EBV感染的胃癌细胞系、患者的肿瘤组织以及动物模型中表达，而BHRF1 miRNAs则不表达。病毒miRNAs在EBVaGCs中的表达提示这些EBV miRNAs可能在EBVaGCs的肿瘤发生中起重要作用。
Epstein-Barr virus (EBV) is associated with about 6 to 16% of gastric carcinoma cases worldwide. Expression of the EBV microRNAs (miRNAs) was observed in B cells and nasopharyngeal carcinoma cells infected with EBV. However, it is not clear if the EBV miRNAs are expressed in EBV-associated gastric carcinomas (EBVaGCs). We found that BART miRNAs but not BHRF1 miRNAs were expressed in EBV-infected gastric carcinoma cell lines and the tumor tissues from patients as well as the animal model. The expression of viral miRNAs in EBVaGCs suggests that these EBV miRNAs may play important roles in the tumorigenesis of EBVaGCs.