Assessment of pathology reports on hilar cholangiocarcinoma: The results of a nationwide, multicenter survey performed by the AFC-HC-2009 study group
Assessment of pathology reports on hilar cholangiocarcinoma: The results of a nationwide, multicenter survey performed by the AFC-HC-2009 study group
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DOI：
10.1016/j.jhep.2011.12.010
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发表时间：
2012-01-01
影响因子：
25.7
通讯作者：
Regimbeau, Jean-Marc
中科院分区：
文献类型：
--
作者：
Chatelain, Denis;Farges, Olivier;Regimbeau, Jean-Marc
背景和目标：目的：评价肝门部胆管癌手术病理报告的准确性。方法：回顾性分析22个三级肝胆中心263例手术病理报告。报告格式，周转时间，组织标本，术中咨询，宏观和微观的描述，和conclusions进行了assessed.Results：外科医生提供的病理学家与相关的临床和影像学数据，只有14%的情况下，并提供信息标本的方向，只有24%的情况下。这些报告经常未能提供关于预后组织学因素的信息：肿瘤分化（27%的病例缺失）、血管浸润（45%）、肿瘤厚度（99%）和胆管手术切缘浸润（4%）。分别有87%、79%和89%的病例肿瘤与血管边缘、肝脏边缘和导管周围软组织边缘之间的距离未明确。只有21%的报告在结论部分给出了pTNM分期。48%的病例因缺乏信息而无法进行回顾性pTNM分期。百分之三的报告有差异，在其conclusion section.Conclusions：我们的法国，全国范围内的研究表明，肝门胆管癌的病理报告往往缺乏重要的信息，主要的预后组织学因素和pTNM分期。我们建议在这种情况下使用标准化的病理报告。(C)2012年欧洲肝脏研究协会。Elsevier B.V.出版，保留所有权利。
Background & Aims: To assess the accuracy of pathology reports in patients operated on for hilar cholangiocarcinoma.Methods: Pathology reports for 263 patients operated on in 22 tertiary hepatobiliary centers were reviewed. The report format, turnaround time, tissue specimens, intraoperative consultations, macroscopic and microscopic descriptions, and conclusions were assessed.Results: Surgeons provided pathologists with pertinent clinical and imaging data in only 14% of cases and gave information on specimen orientation in only 24% of cases. The reports frequently failed to give information on prognostic histological factors: tumor differentiation (missing in 27% of cases), vascular invasion (45%), tumor thickness (99%), and infiltration of the bile duct surgical margins (4%). Distances between the tumor and the vessel margin, liver margin and the periductal soft tissue circumferential margin were not specified in 87%, 79%, and 89% of cases, respectively. Only 21% of the reports gave the pTNM stage in the conclusion section. A lack of information prevented retrospective pTNM staging in 48% of cases. Three percent of the reports had discrepancies in their conclusion section.Conclusions: Our French, nationwide study revealed that pathology reports on hilar cholangiocarcinoma frequently lack important information on the main prognostic histological factors and pTNM staging. We recommend the use of a standardized pathology report in this context. (C) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.