A scalable pipeline for designing reconfigurable organisms
A scalable pipeline for designing reconfigurable organisms
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DOI：
10.1073/pnas.1910837117
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发表时间：
2020-01-28
影响因子：
11.1
通讯作者：
Bongard, Josh
中科院分区：
文献类型：
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作者：
Kriegmana, Sam;Blackiston, Douglas;Bongard, Josh
生命系统比迄今为止创造的任何技术都更强大，更多样，更复杂，更能支持人类生活。然而，我们创造新生命形式的能力目前仅限于改变现有的生物体或体外生物工程类器官。在这里，我们展示了一个可扩展的管道，用于创建功能新颖的生命形式：人工智能方法自动设计不同的候选生命形式，以执行一些所需的功能，然后使用基于细胞的构建工具包创建可转移的设计，以实现具有预测行为的生命系统。尽管这一过程中的某些步骤仍然需要人工干预，但未来完全自动化将为设计和部署独特的定制生活系统铺平道路。
Living systems are more robust, diverse, complex, and supportive of human life than any technology yet created. However, our ability to create novel lifeforms is currently limited to varying existing organisms or bioengineering organoids in vitro. Here we show a scalable pipeline for creating functional novel lifeforms: Al methods automatically design diverse candidate lifeforms in silico to perform some desired function, and transferable designs are then created using a cell-based construction toolkit to realize living systems with the predicted behaviors. Although some steps in this pipeline still require manual intervention, complete automation in future would pave the way to designing and deploying unique, bespoke living systems for a wide range of functions.