Human gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposomes.
Human gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposomes.
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DOI：
10.1089/10430340460732472
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发表时间：
2004-07
影响因子：
4.2
通讯作者：
J. Yoshida;M. Mizuno;M. Fujii;Y. Kajita;Norimoto Nakahara;M. Hatano;R. Saito;Misato Nobayashi;T. Wakabayashi
中科院分区：
文献类型：
--
作者：
J. Yoshida;M. Mizuno;M. Fujii;Y. Kajita;Norimoto Nakahara;M. Hatano;R. Saito;Misato Nobayashi;T. Wakabayashi
已发现通过阳离子脂质体转移干扰素β基因可诱导实验性胶质瘤消退。我们在5例恶性胶质瘤（多形性胶质母细胞瘤或间变性星形细胞瘤）患者中进行了一项试验性临床试验，以评估这种干扰素β基因治疗的安全性和有效性。在4例患者中检测到转基因表达和抗肿瘤活性。两名患者显示出部分反应（>50%肿瘤缩小），另外两名患者在开始治疗后10周病情稳定。1例患者因既往接受过伽玛刀治疗而无法评价。本研究提示干扰素β基因治疗的可行性和安全性，有可能成为恶性胶质瘤患者的一种重要治疗选择。
Transfer of interferon beta gene via cationic liposomes has been found to induce regression of experimental glioma. We performed a pilot clinical trial of safety and effectiveness of this interferon beta gene therapy in five patients with malignant glioma (glioblastoma multiforme or anaplastic astrocytoma). Transgene expression and antitumor activity were detected in four patients. Two patients showed a partial response (>50% tumor reduction) and two others had stable disease 10 weeks after beginning therapy. One patient could not be evaluated because of previous treatment with gamma-knife therapy. This study suggests the feasibility and safety of interferon beta gene therapy, which may become an important treatment option for patients with malignant glioma.