The 67 kDa laminin receptor as a prognostic factor in human cancer
The 67 kDa laminin receptor as a prognostic factor in human cancer
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DOI：
10.1023/a:1006171403765
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发表时间：
1998-01-01
影响因子：
3.8
通讯作者：
Colnaghi, MI
中科院分区：
文献类型：
--
作者：
Ménard, S;Tagliabue, E;Colnaghi, MI
粘附分子的不同受体，包括单体 67 kDa 层粘连蛋白受体 (67LR)，负责肿瘤细胞与细胞外基质成分之间的相互作用，在肿瘤侵袭和转移中发挥重要作用。临床数据清楚地证明了 67LR 在多种肿瘤进展中的重要性，包括乳腺癌、肺癌、卵巢癌、前列腺癌和淋巴瘤。事实上，通过免疫组织化学研究的 4000 多例来自不同器官的不同肿瘤的数据都与 67LR 在侵袭、转移甚至肿瘤生长中的作用一致。该受体分子似乎不寻常，因为相应的全长基因编码 37 kDa 前体蛋白，该前体蛋白在酰化后二聚化生成成熟的 67 kDa 形式。膜受体的主要功能是稳定层粘连蛋白与细胞表面整合素的结合，充当整合素辅助分子，尽管编码受体前体的基因与其他基因的同源性表明了其他功能。为定义这种层粘连蛋白受体的结构、表达和功能而进行的研究代表了开发针对该分子的治疗策略的一步。特别是，下调肿瘤细胞上受体表达的治疗方法可能会导致肿瘤侵袭性降低。
Different receptors for adhesion molecules, including the monomeric 67 kDa laminin receptor (67LR), are responsible for the interactions between tumor cells and components of the extracellular matrix that play an important role in tumor invasion and metastasis. Clinical data clearly demonstrate the importance of the 67LR in the progression of a wide variety of tumors, including breast, lung, ovary, and prostate carcinomas and lymphomas. Indeed, data on more than 4000 cases of different tumors from different organs studied by immunohistochemistry are all concordant with a role for the 67LR in invasiveness, metastasis, and even tumor growth. This receptor molecule appears to be unusual since the corresponding full-length gene encodes a 37 kDa precursor protein which, after acylation, dimerizes to generate the mature 67 kDa form. The primary function of the membrane receptor is to stabilize the binding of laminin to cell surface integrins, acting as an integrin-accessory molecule, although homology of the gene encoding the receptor precursor with other genes suggests additional functions. Studies conducted to define the structure, expression, and function of this laminin receptor represent a step toward developing therapeutic strategies that target this molecule. In particular, therapeutic approaches that downregulate expression of the receptor on tumor cells might lead to decreased tumor aggressiveness.