High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux
High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux
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DOI：
10.1067/mic.2003.11
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发表时间：
2003-04-01
影响因子：
4.9
通讯作者：
Schweizer, HP
中科院分区：
文献类型：
--
作者：
Chuanchuen, R;Karkhoff-Schweizer, RR;Schweizer, HP
背景资料：方法：采用琼脂掺入法和确定的突变株，研究多药外排泵对高浓度三氯生的贡献，（> 1000 μ g/mL）的三氯生耐药性。结果表明，铜绿假单胞菌在三氯生浓度超过1000 μ g/ml时存活的能力明显降低。mL仅归因于外排泵的表达。
Background: Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan.Methods: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (> 1000 mug/mL) triclosan resistance in P aeruginosa was assessed.Results: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1000 mug/mL is solely attributable to the expression of efflux pumps.