A new generation of magnetoencephalography: Room temperature measurements using optically-pumped magnetometers.
A new generation of magnetoencephalography: Room temperature measurements using optically-pumped magnetometers.
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DOI：
10.1016/j.neuroimage.2017.01.034
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发表时间：
2017-04-01
期刊：
影响因子：
5.7
通讯作者：
Brookes MJ
中科院分区：
文献类型：
--
作者：
Boto E;Meyer SS;Shah V;Alem O;Knappe S;Kruger P;Fromhold TM;Lim M;Glover PM;Morris PG;Bowtell R;Barnes GR;Brookes MJ
量子传感领域的进步意味着在室温下工作的磁场传感器现在能够实现与低温冷却设备（SQUID）类似的灵敏度。这意味着，室温脑磁图（MEG），传感器放置的灵活性大大增加，现在可以考虑。此外，这些新的传感器可以直接放置在头皮表面上，理论上，测量信号的幅度会大幅增加。在这里，我们展示了使用单个光泵磁力计（OPM）与3D打印头模相结合进行的记录，该头模旨在相对于大脑解剖结构准确定位和定向传感器。由于我们的OPM被配置为磁力计，因此对环境干扰高度敏感。然而，我们表明，这个问题可以通过使用同时参考传感器记录得到改善。使用正中神经刺激，我们表明，OPM可以检测诱发（锁相）和诱导（非锁相振荡）的变化时，放置在感觉皮层，信号约4倍大于等效SQUID测量。使用源建模，我们表明，我们的系统允许本地化的体感皮层的诱发反应。此外，源空间建模表明，13个连续的OPM测量，源空间的信号噪声比（SNR）是可比的，从271通道SQUID系统。我们的研究结果突出了由OPM产生非制冷、潜在低成本、高SNR MEG系统的机会。
Advances in the field of quantum sensing mean that magnetic field sensors, operating at room temperature, are now able to achieve sensitivity similar to that of cryogenically cooled devices (SQUIDs). This means that room temperature magnetoencephalography (MEG), with a greatly increased flexibility of sensor placement can now be considered. Further, these new sensors can be placed directly on the scalp surface giving, theoretically, a large increase in the magnitude of the measured signal. Here, we present recordings made using a single optically-pumped magnetometer (OPM) in combination with a 3D-printed head-cast designed to accurately locate and orient the sensor relative to brain anatomy. Since our OPM is configured as a magnetometer it is highly sensitive to environmental interference. However, we show that this problem can be ameliorated via the use of simultaneous reference sensor recordings. Using median nerve stimulation, we show that the OPM can detect both evoked (phase-locked) and induced (non-phase-locked oscillatory) changes when placed over sensory cortex, with signals ~4 times larger than equivalent SQUID measurements. Using source modelling, we show that our system allows localisation of the evoked response to somatosensory cortex. Further, source-space modelling shows that, with 13 sequential OPM measurements, source-space signal-to-noise ratio (SNR) is comparable to that from a 271-channel SQUID system. Our results highlight the opportunity presented by OPMs to generate uncooled, potentially low-cost, high SNR MEG systems.
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影响因子：
3.7
作者：
Boto E;Bowtell R;Krüger P;Fromhold TM;Morris PG;Meyer SS;Barnes GR;Brookes MJ
通讯作者：
Brookes MJ
影响因子：
3.5
作者：
Johnson CN;Schwindt PD;Weisend M
通讯作者：
Weisend M
影响因子：
5.7
作者：
Hillebrand, A;Barnes, GR
通讯作者：
Barnes, GR
影响因子：
3
作者：
Meyer, Sofie S.;Bonaiuto, James;Barnes, Gareth R.
通讯作者：
Barnes, Gareth R.
影响因子：
4
作者：
Dang, H. B.;Maloof, A. C.;Romalis, M. V.
通讯作者：
Romalis, M. V.