On the relationship status for Arf and NPM1 - it's complicated.
On the relationship status for Arf and NPM1 - it's complicated.
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DOI：
10.1111/febs.14407
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Kriwacki RW
中科院分区：
文献类型：
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作者：
Mitrea DM;Kriwacki RW
ARF水平在细胞内受到严格调控，并与核糖体的生物发生和细胞的增殖状态密切相关。通过与核糖体生物发生调节器NPM1和细胞命运调节器MDM2的多价相互作用，Arf整合到核仁基质中，改变其结构、动力学和功能，从而调节细胞周期。ARF水平在细胞内受到严格调控，并与核糖体的生物发生和细胞的增殖状态密切相关。通过与核糖体生物发生调节器NPM1和细胞命运调节器MDM2的多价相互作用，Arf整合到核仁基质中，改变其结构、动力学和功能，从而调节细胞周期。
Arf levels are tightly regulated in cells and correlate with the level of ribosome biogenesis and proliferative status of cells. Through multivalent interactions with NPM1 – a regulator of ribosome biogenesis, and Mdm2 – a regulator of cellular fate, Arf integrates within the nucleolar matrix, altering its structure, dynamics and function and therefore modulates the cell cycle. Arf levels are tightly regulated in cells and correlate with the level of ribosome biogenesis and proliferative status of cells. Through multivalent interactions with NPM1 – a regulator of ribosome biogenesis, and Mdm2 – a regulator of cellular fate, Arf integrates within the nucleolar matrix, altering its structure, dynamics and function and therefore modulates the cell cycle.