The erythrocytes in paroxysmal nocturnal haemoglobinuria of intermediate sensitivity to complement lysis
The erythrocytes in paroxysmal nocturnal haemoglobinuria of intermediate sensitivity to complement lysis
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阵发性睡眠性血红蛋白尿中的红细胞对补体溶解具有中等敏感性
DOI：
--
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发表时间：
1991
影响因子：
6.5
通讯作者：
C. Parker
中科院分区：
文献类型：
--
作者：
W. Rosse;Sharon N. Hoffman;Milton Campbell;Michael J. Borowitz;J. Moore;C. Parker
The sensitivity to lysis by complement of the erythrocytes of 56 patients with paroxysmal nocturnal haemoglobinuria (PNH) was compared to the membrane expression of decay accelerating factor (DAF, CD55), membrane inhibitor of reactive lysis (MIRL, CD59) and acetylcholinesterase (AChE). Most patients (36/50 72% in whom the analysis could be made) appeared to have erythrocytes of intermediate sensitivity to complement in the blood. These cells appeared as a discrete population of cells (PNH II cells), as a ‘tail’ of cells slightly less sensitive than the predominant PNH III cells (previously called PNH IIIb cells), or as a continuous spectrum of cells sensitive to complement. The PNH III cells totally lacked all three proteins (DAF, MIRL, AChE) by flow cytometric analysis whereas PNH I cells appeared to have normal or nearly normal amounts of each. The cells of intermediate sensitivity (PNH II) had coordinately decreased expression of all three proteins; the level of expression of DAF and MIRL paralleled the sensitivity of the cells to the haemolytic action of complement.
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DOI：
10.1073/pnas.85.3.880
发表时间：
1988
影响因子：
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作者：
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作者：
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通讯作者：
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DOI：
10.1172/jci114432
发表时间：
1990
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Carothers,DJ;Hazra,SV;Andreson,SW;Medof,ME
通讯作者：
Medof,ME
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影响因子：
20.3
作者：
Chow,FL;Hall,SE;Rosse,WF;Telen,MJ
通讯作者：
Telen,MJ
影响因子：
15.9
作者：
HOLGUIN, MH;FREDRICK, LR;PARKER, CJ
通讯作者：
PARKER, CJ