The risk of lung cancer among cooking adults: a meta-analysis of 23 observational studies
The risk of lung cancer among cooking adults: a meta-analysis of 23 observational studies
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DOI：
10.1007/s00432-017-2547-7
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发表时间：
2018-02-01
影响因子：
3.6
通讯作者：
Sun, Xin
中科院分区：
文献类型：
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作者：
Jia, Peng-Li;Zhang, Chao;Sun, Xin
目的 烹饪被认为是肺癌的潜在危险因素。我们的目的是调查烹饪油烟与肺癌风险的证据。方法 检索 Medline 和 Embase 中符合条件的研究。我们进行了荟萃分析来总结病例对照或队列研究的证据，并对潜在差异进行亚组分析。采用敏感性分析来检验稳健性。结果 我们纳入了 23 项观察性研究，涉及 9411 例肺癌病例。我们的荟萃分析发现，对于烹饪女性来说，非吸烟人群中烹饪油烟暴露的汇总 OR 为 1.98（95% CI 1.54, 2.54，I-2 = 79%，n = 15），部分吸烟人群中则为 2.00（95% CI 1.46, 2.74，I-2 = 75%，n = 10）。对于烹饪男性，肺癌的汇总 OR 为 1.15（95% CI 0.71, 1.87；I-2 = 80%，n = 4）。按通气条件分组时，与通气良好相比，通气不良的汇总 OR 为 1.20（95% CI 1.10、1.31、I-2 = 2%）。对于不同的烹饪方法，我们的结果表明，炒菜（OR = 1.89，95% CI 1.23, 2.90；I-2 = 66%）与肺癌风险增加相关，而油炸则不然（OR = 1.41，95% CI 0.87, 2.29；I-2 = 5%）。敏感性分析表明我们的结果是稳定的。结论无论吸烟状况如何，烹饪油烟可能是女性肺癌的危险因素。通风不良可能会增加患肺癌的风险。烹饪方法可能对肺癌有不同的影响，油炸可能比炒更健康。
Purpose Cooking has been regarded as a potential risk factor for lung cancer. We aim to investigate the evidence of cooking oil fume and risk of lung cancer.Methods Medline and Embase were searched for eligible studies. We conducted a meta-analysis to summarize the evidences of case-control or cohort studies, with subgroup analysis for the potential discrepancy. Sensitivity analysis was employed to test the robustness.Results We included 23 observational studies, involving 9411 lung cancer cases. Our meta-analysis found that, for cooking female, the pooled OR of cooking oil fume exposure was 1.98 (95% CI 1.54, 2.54, I-2 = 79%, n = 15) among non-smoking population and 2.00 (95% CI 1.46, 2.74, I-2 = 75%, n = 10) among partly smoking population. For cooking males, the pooled OR of lung cancer was 1.15 (95% CI 0.71, 1.87; I-2 = 80%, n = 4). When sub grouped by ventilation condition, the pooled OR for poor ventilation was 1.20 (95% CI 1.10, 1.31, I-2 = 2%) compared to good ventilation. For different cooking methods, our results suggested that stir frying (OR = 1.89, 95% CI 1.23, 2.90; I-2 = 66%) was associated with increased risk of lung cancer while not for deep frying (OR = 1.41, 95% CI 0.87, 2.29; I-2 = 5%). Sensitivity analysis suggested our results were stable.Conclusion Cooking oil fume is likely to be a risk factor for lung cancer for female, regardless of smoking status. Poor ventilation may increase the risk of lung cancer. Cooking methods may have different effect on lung cancer that deep frying may be healthier than stir frying.