Health-related quality of life, work productivity and health care resource use associated with constipation predominant irritable bowel syndrome
Health-related quality of life, work productivity and health care resource use associated with constipation predominant irritable bowel syndrome
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DOI：
10.1185/03007995.2011.623157
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发表时间：
2011-11-01
影响因子：
2.3
通讯作者：
Mody, Reema
中科院分区：
文献类型：
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作者：
DiBonaventura, Marco;Sun, Shawn X.;Mody, Reema
目的：肠易激综合征（IBS）是一种常见的胃肠道疾病，在美国的患病率从10%到15%不等。本研究的目的是评估IBS-C对健康相关的生活质量（HRQOL），工作效率和活动障碍，和卫生保健resource utilization.Methods：使用数据从2007年美国国家健康和健康调查，IBS-C患者（n=789）进行了比较的倾向评分匹配的对照组（n 789）。两组之间的差异进行了检查HRQOL（SF-12 v2），工作效率和活动障碍（WPAI问卷），并自我报告的资源使用在过去6 months.Results：IBS-C患者报告的HRQOL水平显着降低（身体成分总评分：41.55 [95%CI：40.72-42.37]对44.49 [95%CI：40.72-42.37]。43.67-45.31];心理健康总分：40.58 [95% CI：39.75-41.40] vs. 45.87 [95% CI：45.04-46.70]），以及出勤率的平均水平显著较高（31.72% [95%CI：28.25%-35.61%] vs 21.43% [95%CI：19.03%-24.15%]），总体工作障碍（35.54% [95% CI：31.76%-39.76%] vs. 25.29% [95% CI：22.59%-28.30%]）和活动障碍（45.78% [95% CI：43.08%-48.66%] vs. 33.03% [95% CI：. 31.08%-35.11%]）高于匹配的对照药物（所有P值
Objectives:Irritable bowel syndrome (IBS) is a common gastrointestinal disorder, Prevalence estimates of IBS vary widely, from 10 to 15% in the U.S However, few studies have examined constipation predominant IBS (IBS-C), a subtype of IBS. The aim of this study was to assess the effect of IBS-C on health-related quality of life (HRQOL), work productivity and activity impairment, and health care resource use.Methods:Using data from the 2007 U.S. National Health and Wellness Survey, IBS-C patients (n=789) were compared to a propensity-score matched comparison group (n 789). Differences between the groups were examined on HRQOL (SF-12v2), work productivity and activity impairment (WPAI questionnaire), and self-reported resource use in the last 6 months.Results:Patients with IBS-C reported significantly lower levels of HRQOL (physical component summary score: 41.55 [95% CI: 40.72-42.37] versus 44.49 [95% CI. 43.67-45.31]; mental component summary score: 40.58 [95% CI: 39.75-41.40] vs. 45.87 [95% CI: 45.04-46.70]) and significantly higher mean levels of presenteeism (31.72% [95% CI: 28.25%-35.61%] vs. 21.43% [95% CI: 19.03%-24.15%]), overall work impairment (35.54% [95% CI: 31.76%-39.76%] vs. 25.29% [95% CI: 22.59%-28.30%]), and activity impairment (45.78% [95% CI: 43.08%-48.66%] vs. 33.03% [95% CI:. 31.08%-35.11%]) than matched comparators (all P values