Lack of pineal beta-adrenergic receptor alterations in suicide victims with major depression.
Lack of pineal beta-adrenergic receptor alterations in suicide victims with major depression.
复制标题
患有重度抑郁症的自杀受害者缺乏松果体β-肾上腺素能受体改变。
DOI：
10.1016/s0306-4530(96)00031-5
复制
发表时间：
1997
影响因子：
3.7
通讯作者：
Clark,TB
中科院分区：
文献类型：
--
作者：
Little,KY;Ranc,J;Gilmore,J;Patel,A;Clark,TB
去甲肾上腺素能功能可能在抑郁症中发生改变，从而导致松果体产生的褪黑激素水平降低，正如之前在一些抑郁症受试者中所描述的那样。在本研究中，测试了以下假设：有抑郁症证据的自杀者的松果体β-肾上腺素能结合会增加，反映出去甲肾上腺素能输入减少。最初，死后的人类松果体是通过尸检获得的。然后使用标准化访谈技术从家庭成员系统地收集诊断和症状信息。七名自杀并患有重度抑郁症且未接受抑郁症状治疗的受试者与对照受试者年龄和性别匹配。使用四种浓度的[125I]吲哚洛尔通过定量放射自显影评估松果体β-肾上腺素能结合。由于松果体的肾上腺素能调节可能很复杂，因此使用选择性阻滞剂 ICI 89406 对 β-肾上腺素能受体结合进行亚型分类。与匹配的对照相比，重度抑郁症受试者之间未检测到 β-肾上腺素能受体存在差异。
Noradrenergic function may be altered in depressive illness and thereby contribute to decreased pineal production of melatonin levels, as previously described in some depressed subjects. In the present study, the hypothesis was tested that pineal β-adrenergic binding would be increased in persons committing suicide with evidence of depressive disorders, reflecting diminished noradrenergic input. Initially, post-mortem human pineal glands were obtained at autopsy. Diagnostic and symptomatic information was then systematically collected from family members using standardized interview techniques. Seven subjects who committed suicide and suffered from major depression, and without exposure to treatment for depressive symptoms were age- and sex-matched with control subjects. Pineal β-adrenergic binding was assessed by quantitative autoradiography employing four concentrations of [125I]pindolol. Because of possibly complex adrenergic regulation of the pineal, β-adrenergic receptor binding were subtyped using the selective blocker ICI 89406. No differences in β-adrenergic receptors were detected between subjects with major depression compared to the matched controls.