Accelerating adolescent HIV research in low-income and middle-income countries: evidence from a research consortium.
Accelerating adolescent HIV research in low-income and middle-income countries: evidence from a research consortium.
复制标题
在低收入和中等收入国家中加速青少年艾滋病毒研究：研究财团的证据。
DOI：
10.1097/qad.0000000000003049
复制
发表时间：
2021-12-01
期刊：
影响因子：
--
通讯作者：
Kapogiannis BG
中科院分区：
文献类型：
--
作者：
Tucker JD;Iwelunmor J;Abrams E;Donenberg G;Wilson EC;Blachman-Demner D;Laimon L;Taiwo BO;Kuhns LM;John-Stewart GC;Kohler P;Subramanian S;Ayieko J;Gbaja-Biamila T;Oladele D;Obiezu-Umeh C;Chima KP;Jalil EM;Falcao J;Ezechi OC;Kapogiannis BG
许多青少年和年轻人（AYA）的艾滋病毒预防需求未得到满足。我们描述了预防和治疗，通过一个全面的护理连续的艾滋病毒影响的青少年在资源有限的设置（PATC 3 H）财团组织，过渡里程碑，和青年参与战略。PATC 3 H联盟的重点是减少艾滋病毒的发病率和相关的健康差距AYA。组织数据来自Eunice Kennedy Shriver国家儿童健康和人类发展研究所（NICHD），并补充了由研究主要研究者完成的简短调查。从初始阶段（1-2年）过渡到后续阶段（3-5年）取决于是否达到预先规定的里程碑。我们审查了研究联盟的结构和功能，确定了过渡里程碑的共同要素，并审查了共同的青年参与战略。PATC 3 H联盟通过里程碑式的过渡机制支持八项研究。该联盟包括在七个国家----巴西、肯尼亚、莫桑比克、尼日利亚、南非、乌干达和赞比亚----进行的艾滋病毒研究。NIH的申请要求需要过渡里程碑，包括与利益相关者的早期磋商。NIH要求的8项研究的过渡里程碑包括与卫生和政策利益相关者的早期磋商、试点干预数据和国家政府利益相关者的承诺。所有研究都为AYA的参与提供了多种途径，包括AYA咨询委员会和青年主导的研究。数据表明，要求里程碑过渡到最后阶段可能促进了卫生和政策利益攸关方的参与，并加强了对监管协议的形成性评估。这些数据对设计中低收入国家的参与性研究具有影响。
Many adolescents and young adults (AYA) have unmet HIV prevention needs. We describe the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H) consortium organization, transition milestones, and youth engagement strategies. The PATC3H consortium focuses on reducing HIV incidence and related health disparities among AYA. Organizational data were obtained from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and supplemented with a brief survey completed by study principal investigators. Transition from the initial phase (years 1–2) to the subsequent phase (years 3–5) was contingent on meeting pre-specified milestones. We reviewed the structure and function of the research consortium, identified shared elements of transition milestones, and examined common youth engagement strategies. The PATC3H consortium supports eight research studies through a milestone transition mechanism. The consortium includes AYA HIV research studies in seven countries - Brazil, Kenya, Mozambique, Nigeria, South Africa, Uganda, and Zambia. The NIH request for applications required transition milestones that included early consultation with stakeholders. The transition milestones required by NIH for the eight studies included early consultation with health and policy stakeholders, pilot intervention data and commitment from national government stakeholders. All studies provided multiple pathways for AYA engagement, including AYA advisory boards and youth-led research studies. Data suggest that requiring milestones to transition to the final phase may have facilitated health and policy stakeholder engagement and enhanced formative assessment of regulatory protocols. These data have implications for designing engaged research studies in low and middle-income countries.