TACTILE AND AUDITORY-STIMULI REPEATED AT HIGH-RATES (30-50 PER SEC) PRODUCE SIMILAR EVENT RELATED POTENTIALS
TACTILE AND AUDITORY-STIMULI REPEATED AT HIGH-RATES (30-50 PER SEC) PRODUCE SIMILAR EVENT RELATED POTENTIALS
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DOI：
10.1111/j.1749-6632.1982.tb50841.x
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发表时间：
1982-01-01
影响因子：
5.2
通讯作者：
GALAMBOS, R
中科院分区：
文献类型：
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作者：
GALAMBOS, R
只有少数研究人员试图记录刺激频率高于每秒20或30次的事件相关电位(EPR)。Van der Tweel和Verduyn Lumel 6在启动现在被称为稳态视觉ERPs的研究时，以高达约70赫兹的频率施加了正弦调制光刺激，并在整个范围内记录了来自头皮的大约正弦响应。随后，Regan和他的同事们对反应幅度和刺激率的关系进行了广泛的探索，发现了三个ERP幅度峰值，其中一个在40-55 Hz区域。在躯体感觉中，Namerow以每秒100或更高的速度施加正中神经刺激，从覆盖在受刺激肢体皮质投影上的头皮进行记录。在20赫兹以上的刺激率下，可记录到大量正弦形式的事件相关电位，但在特定频率下未发现重要的反应峰值。在试听中，Campbell等人报道了视觉稳态实验的听觉模拟，类似地记录了从椎骨乳突电极到快速重复的滴答声或音调爆发的几乎正弦的ERP。反应幅度随着刺激强度的降低而呈规律性下降，因此该曲线可以用来预测听阈值，具有显著的准确性。Campbell等人。未检查以高于每秒32的速率刺激的事件相关电位。我们最近做了这项工作，并报告了以下主要结果：(1)对许多受试者来说，正弦的稳态ERP幅度在接近每秒40的刺激率时达到峰值，因此我们将这种现象命名为听觉性40赫兹ERP(2)40赫兹ERP具有广泛的头皮分布；(3)它是由各种重复的听觉刺激产生的，包括由低至125赫兹的频率组成的脉冲音调爆发；以及(4)反应似乎代表几种称为听觉中潜伏期反应的ERP波的巩固或叠加。
Only a few investigators have attempted to record event related potentials (EPRs) at stimulus rates above 20 or 30 stimuli per sec (Hz). Van der Tweel and Verduyn Lunel, 6 in initiating the study of what are now called steady-state visual ERPs, applied sinusoidally modulated light stimuli at rates up to about 70 Hz and recorded approximately sinusoidal responses from the scalp throughout this range. Subsequently Regan and colleagues ‘extensively explored the relationship of response amplitude and stimulus rate, identifying three ERP amplitude peaks of which one was in the 40-55 Hz region.In somesthesia Namerow’applied median nerve shocks at rates up to 100 per sec or more, recording from scalp overlying the cortical projection of the stimulated limb. Substantial sinusoidal ERPs were recorded at stimulus rates above 20 Hz but no important response peak was found at a particular frequency. In audition Campbell et al.’have reported the auditory analog of the visual steady-state experiment, similarly recording nearly sinusoidal ERPs from vertexmastoid electrodes to rapidly-repeated clicks or tone bursts. Response amplitude declined so regularly with drop in stimulus intensity that the curve could be used to predict threshold of audibility with remarkable accuracy. Campbell et al. did not examine ERPs to stimuli at rates above 32 per sec. We have recently done this and reported’the following main results:(1) For many subjects sinusoidal, steady-state ERP amplitudes peak at stimulus rates near 40 per sec, and for this reason we have named the phenomenon the auditory 40 Hz ERP (2) the 40 Hz ERP has a widespread scalp distribution;(3) it is produced by a wide range of repetitive auditory stimuli, including pulsed tone bursts made up of frequencies as low as 125 Hz; and (4) the response appears to represent a consolidation, or superimposition of the several ERP waves known as the auditory middle latency response.