Development and function of bombesin-like peptides and their receptors
Development and function of bombesin-like peptides and their receptors
复制标题
DOI：
10.1387/ijdb.041954ho
复制
发表时间：
2005-01-01
影响因子：
0.7
通讯作者：
Maekawa, F
中科院分区：
文献类型：
--
作者：
Ohki-Hamazaki, H;Iwabuchi, M;Maekawa, F
两栖类蛙皮素及其相关肽是脊椎动物神经肽的一个家族。蛙皮素和哺乳动物中两种主要的蛙皮素样肽，胃泌素释放肽（GRP）和神经介肽B（NMB），已被证明引起各种生理效应。这些包括抑制摄食、平滑肌收缩、外分泌和内分泌、体温调节、血压和蔗糖调节以及细胞生长。已经克隆了GRP和NMB的受体（GRP-R和NMB-R）以及蛙皮素样肽受体的第三亚型（BRS-3）。这些受体是G蛋白偶联受体，在大脑的各个区域和消化道中表达。在本文中，我们将总结这些肽及其受体的研究，特别是使用基因敲除小鼠的研究。这些研究清楚地证明了三种受体在体内和体外的作用。我们还将讨论这些受体的遗传。
Amphibian bombesin and its related peptides consist a family of neuropeptides in many vertebrate species. Bombesin and two major bombesin-like peptide in mammals, gastrin-releasing peptide (GRP) and neuromedin B (NMB), have been shown to elicit various physiological effects. These include inhibition of feeding, smooth muscle contraction, exocrine and endocrine secretions, thermoregulation, blood pressure and sucrose regulations and cell growth. Receptors for GRP and NMB (GRP-R and NMB-R), as well as third subtype of bombesin-like peptide receptor (BRS-3) have been cloned. These receptors are G-protein-coupled receptors and are expressed in various brain regions and in the digestive tract. In this paper, we will summarize studies on these peptides and their receptors, with special reference to research using gene-knockout mice. These studies clearly demonstrated the role of three receptors in vivo and in vitro. We will also discuss the phylogeny of these receptors.