Analysis of autoantibody reactivity and common idiotype PR4 expression of myeloma proteins.
Analysis of autoantibody reactivity and common idiotype PR4 expression of myeloma proteins.
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骨髓瘤蛋白自身抗体反应性和常见独特型 PR4 表达分析。
DOI：
10.1016/s0896-8411(89)80007-1
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发表时间：
1989
影响因子：
12.8
通讯作者：
D. Isenberg
中科院分区：
文献类型：
--
作者：
R. Watts;W. Williams;S. Le Page;A. Norden;A. Soltys;G. Swana;I. Addison;F. Hay;D. Isenberg
Sera from 75 patients with monoclonal gammopathies and with no clinical evidence of autoimmune disease have been screened for a wide range of autoreactivity including binding to DNA, cardiolipin, extractable nuclear antigen (ENA), rheumatoid factor activity and the presence of the common anti-DNA antibody idiotype PR4. The sera of 17/75 (23%) patients possessed autoreactivity: six were positive for anti-DNA activity, two had anticardiolipin activity and the PR4 ID was found in two sera (both of which possessed anti-DNA activity). Antibodies to ENA were found in one serum (anti-Ro) and anti-organ-specific antibodies in five. Using iso-electric focusing and immunoblotting we have shown that the PR4 ID and DNA binding activity are carried on the paraprotein and not on some other serum constituent.The IgG subclass distribution of 55 IgG paraproteins has also been investigated. The majority of IgG paraproteins belong to IgG1 subclass (55%), with the others, being IgG2 (4%), IgG3 (9%) and IgG4 (27%).In this study we have shown that sera from myeloma patients frequently possess autoreactivity, and that in many cases this can be attributed to the paraprotein.
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骨髓瘤蛋白的独特型分析：具有 SLE 独特型的单克隆免疫球蛋白的抗 DNA 活性在 IgG 中比 IgM 抗体更常见。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Davidson,A;Preud'homme,JL;Solomon,A;Chang,MD;Beede,S;Diamond,B
通讯作者：
Diamond,B
人类可变区重链种系基因与编码抗 DNA 自身抗体的基因的关系。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Dersimonian,H;Schwartz,RS;Barrett,KJ;Stollar,BD
通讯作者：
Stollar,BD
成人和新生儿正常受试者以及系统性红斑狼疮、干燥综合征和药物引起的自身免疫患者中抗破伤风类毒素抗体的 IgG 亚类。
DOI：
--
发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Rubin,RL;Tang,FL;Lucas,AH;Spiegelberg,HL;Tan,EM
通讯作者：
Tan,EM
人类风湿因子副蛋白的三种交叉反应独特型的发生率。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Crowley,JJ;Goldfien,RD;Schrohenloher,RE;Spiegelberg,HL;Silverman,GJ;Mageed,RA;Jefferis,R;Koopman,WJ;Carson,DA;Fong,S
通讯作者：
Fong,S
DNA 自身抗体。
DOI：
--
发表时间：
1988
期刊：
In vivo (Athens, Greece)
影响因子：
--
作者：
Sabbaga,J;Migliorini,P;Schwartz,RS
通讯作者：
Schwartz,RS