Relationship between Carnitine Deficiency and Tyrosine Kinase Inhibitor Use in Patients with Chronic Myeloid Leukemia
Relationship between Carnitine Deficiency and Tyrosine Kinase Inhibitor Use in Patients with Chronic Myeloid Leukemia
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慢性粒细胞白血病患者肉碱缺乏与酪氨酸激酶抑制剂使用的关系
DOI：
10.1159/000521113
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Hideki Nakamura
中科院分区：
文献类型：
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作者：
Noriyoshi Iriyama;Katsuhiro Miura;Yoshihito Uchino;Hiromichi Takahashi;Masaru Nakagawa;Kazuhide Iizuka;Takashi Hamada;Takashi Koike;Kazuya Kurihara;Tomohiro Nakayama;Masami Takei;Yoshihiro Hatta;Hideki Nakamura
背景：一些化疗药物引起肉碱缺乏，从而引起全身疲劳。然而，尚无研究表明慢性髓性白血病（CML）患者在酪氨酸激酶抑制剂（TKI）治疗期间存在肉碱缺乏症。目的研究经TKI治疗的CML患者的肉碱浓度。方法本研究纳入控制良好的CML患者。用酶循环法测定总肉碱和游离肉碱浓度。使用简短疲劳量表（BFI）和癌症疲劳量表（CFS）评估TKI治疗期间的一般疲劳。结果共纳入55例TKI治疗患者。其中，12例（21.8%）患者游离肉碱浓度低。游离肉碱浓度在男性中高于女性。年龄越小，游离肉碱浓度越低。TKI类型、TKI剂量、治疗反应或治疗持续时间与游离肉碱浓度无关。所有评分（包括BFI评分和CFS评分）均与肉毒碱浓度无关。无治疗缓解组游离肉毒碱浓度略高于TKI组，只有9.1%的患者游离肉毒碱浓度较低。结论左旋肉碱缺乏可能不是引起全身疲劳的主要原因，但可能发生在接受TKI治疗的CML患者中。
BackgroundSome chemotherapeutic agents cause carnitine deficiency, which causes general fatigue. However, there is no study on carnitine deficiency in patients with chronic myeloid leukemia (CML) during tyrosine kinase inhibitor (TKI) therapy.ObjectiveIn this study, we investigated carnitine concentrations in patients with CML receiving TKI therapy.MethodThis study included patients with well-controlled CML. Total carnitine and free carnitine concentrations were evaluated using the enzyme cycling method. The brief fatigue inventory (BFI) and cancer fatigue scale (CFS) were used to assess general fatigue developed during TKI therapy.ResultsFifty-five patients on TKI therapy were included. Of these, 12 (21.8%) patients had low free carnitine concentrations. Free carnitine concentrations were higher in men than in women. Younger age was closely associated with lower free carnitine concentrations. TKI type, TKI dose, treatment response, or therapy duration were not associated with free carnitine concentrations. None of the scores (the global fatigue score with the BFI and CFS score) correlated with carnitine concentrations. Concentrations of free carnitine in patients in the treatment-free remission group were slightly higher than those in the TKI group, with only 9.1% having a low concentration of free carnitine.ConclusionCarnitine deficiency is probably not a major cause of general fatigue but may occur in patients with CML receiving TKI therapy.