One-flask synthesis of cyclic diguanosine monophosphate (c-di-GMP).
One-flask synthesis of cyclic diguanosine monophosphate (c-di-GMP).
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DOI：
10.1002/0471142700.nc1408s48
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发表时间：
2012-03-01
影响因子：
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通讯作者：
Jones, Roger A
中科院分区：
文献类型：
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作者：
Gaffney, Barbara L;Jones, Roger A
细菌信号分子环二鸟苷单磷酸(c-di-GMP)在控制生物膜形成和致病毒力等诸多功能中起着关键作用。它对人类健康具有广泛的后果，目前的研究正在积极探索其分子机制。这里描述的方便的一瓶，克规模的c-di-GMP的合成将促进这些努力。
The bacterial signaling molecule, cyclic diguanosine monophosphate (c-di-GMP), plays a key role in controlling biofilm formation and pathogenic virulence, among many other functions. It has widespread consequences for human health, and current research is actively exploring its molecular mechanisms. The convenient one-flask, gram-scale synthesis of c-di-GMP described here will facilitate these efforts.