Efavirenz liquid formulation in human immunodeficiency virus-infected children
Efavirenz liquid formulation in human immunodeficiency virus-infected children
复制标题
依非韦伦液体制剂治疗人类免疫缺陷病毒感染儿童
DOI：
--
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
M. Kline
中科院分区：
文献类型：
--
作者：
S. Starr;C. Fletcher;S. Spector;R. Brundage;F. H. Yong;S. Douglas;P. Flynn;M. Kline
Background. This study determined the safety, pharmacokinetics, antiviral activity and immunologic effects of efavirenz liquid formulation, nelfinavir and nucleoside reverse transcriptase inhibitors (NRTIs) in HIV-infected children, 3 to 9 years of age. Methods. Plasma HIV-1 RNA and lymphocyte subsets were measured at various intervals after initiation of therapy. Pharmacokinetic studies were performed at Week 2, and doses of efavirenz and nelfinavir were adjusted if area under the curve values fell outside specified target ranges. Results. This combination of antiretrovirals was well-tolerated. Pharmacokinetic values were similar to those observed in a previous study of older children who received efavirenz capsules in combination with nelfinavir and NRTIs. After 48 weeks of therapy 63% of subjects had plasma HIV RNA levels of <400 copies/ml, and 58% had <50 copies/ml in an intent-to-treat analysis. CD4 cell count and percentage rose significantly over this time, whereas the number of activated CD8 cells declined. Conclusions. Combination therapy with efavirenz liquid formulation, nelfinavir and NRTIs is an attractive treatment option for HIV-infected children >3 years of age who are unable to take efavirenz capsules.
登录
查看更多内容
受感染儿童血浆人类免疫缺陷病毒 1 型 RNA 对高效抗逆转录病毒治疗的反应模式。
DOI：
10.1086/317621
发表时间：
2000
期刊：
The Journal of infectious diseases.
影响因子：
--
作者：
Spector,SA;Hsia,K;Yong,FH;Cabral,S;Fenton,T;Fletcher,CV;McNamara,J;Mofenson,LM;Starr,SE
通讯作者：
Starr,SE
奈非那韦在人类免疫缺陷病毒感染婴儿中的药代动力学。
DOI：
10.1097/00006454-200108000-00006
发表时间：
2001
期刊：
The Pediatric infectious disease journal
影响因子：
--
作者：
Capparelli,EV;Sullivan,JL;Mofenson,L;Smith,E;Graham,B;Britto,P;Becker,MI;Holland,D;Connor,JD;Luzuriaga,K;PediatricACTG356Investigators
通讯作者：
PediatricACTG356Investigators
DOI：
10.1086/315672
发表时间：
2000-07
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
W. Borkowsky;K. Stanley;S. Douglas;Sophia S. Lee;A. Wiznia;S. Pelton;R. Yogev;K. Mcintosh;S. Nachman
通讯作者：
W. Borkowsky;K. Stanley;S. Douglas;Sophia S. Lee;A. Wiznia;S. Pelton;R. Yogev;K. Mcintosh;S. Nachman
人类免疫缺陷病毒感染儿童利托那韦治疗后的免疫重建涉及多种淋巴细胞谱系。
DOI：
10.1016/s0022-3476(99)70247-7
发表时间：
1999
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Sleasman,JW;Nelson,RP;Goodenow,MM;Wilfret,D;Hutson,A;Baseler,M;Zuckerman,J;Pizzo,PA;Mueller,BU
通讯作者：
Mueller,BU