Aggregatibacter actinomycetemcomitans and Filifactor alocis: Two exotoxin-producing oral pathogens.
Aggregatibacter actinomycetemcomitans and Filifactor alocis: Two exotoxin-producing oral pathogens.
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DOI：
10.3389/froh.2022.981343
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发表时间：
2022
影响因子：
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通讯作者：
Uriarte, Silvia M
中科院分区：
文献类型：
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作者：
Ozuna, Hazel;Snider, Ian;Belibasakis, Georgios N;Oscarsson, Jan;Johansson, Anders;Uriarte, Silvia M
牙周炎是一种由疾病中存在的微生物生态系统与失调的宿主免疫反应之间的相互作用引起的一种非生态性疾病。与疾病相关的微生物群落是由已有的口腔病原体(如伴生放线菌Aggregatibacter)和新的优势种(如Filifacealocis)形成的。这两种口腔病原体在牙周袋中流行并生长，这突显了它们逃避宿主免疫反应的能力。本文综述了两种口腔病原菌在牙周炎中的毒力因子和潜在致病力，重点介绍了近年来对金黄色葡萄球菌毒力因子的描述，包括一种外毒素的存在，并将它们与伴生放线菌相关的已知因子进行了比较。在疾病背景下，两种口腔病原体之间可能的协同和/或互惠作用可能有助于疾病的进展。
Periodontitis is a dysbiotic disease caused by the interplay between the microbial ecosystem present in the disease with the dysregulated host immune response. The disease-associated microbial community is formed by the presence of established oral pathogens like Aggregatibacter actinomycetemcomitans as well as by newly dominant species like Filifactor alocis. These two oral pathogens prevail and grow within the periodontal pocket which highlights their ability to evade the host immune response. This review focuses on the virulence factors and potential pathogenicity of both oral pathogens in periodontitis, accentuating the recent description of F. alocis virulence factors, including the presence of an exotoxin, and comparing them with the defined factors associated with A. actinomycetemcomitans. In the disease setting, possible synergistic and/or mutualistic interactions among both oral pathogens might contribute to disease progression.