BMP4 expression in the adult rat brain
BMP4 expression in the adult rat brain
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发表时间：
2006-10
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通讯作者：
S. Mikawa;Cong Wang;Kohji Sato
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作者：
S. Mikawa;Cong Wang;Kohji Sato
骨形态发生蛋白4（BMP-4）是转化生长因子β（TGF-β）超家族成员，在多种生物学事件中发挥重要作用。虽然BMP 4在中枢神经系统（CNS）的早期发育中的表达已被很好地描述，但关于其在成人CNS中的表达的信息很少。因此，我们研究了BMP 4在成年大鼠中枢神经系统的表达，采用免疫组织化学。BMP 4在大多数神经元及其树突中强烈表达。此外，在报告具有高可塑性的灰质的神经元层中也观察到强烈的BMP 4表达，例如小脑的分子层和上级丘的浅层。此外，我们发现星形胶质细胞也表达BMP 4蛋白。这些数据表明，BMP 4在整个成人CNS中比以前报道的更广泛地表达，并且其在成人脑中的持续丰富表达强烈支持BMP 4在成人脑中也起关键作用的观点。
Bone morphogenetic protein-4 (BMP4) is a member of the transforming growth factor β (TGF-β ) superfamily and plays important roles in multiple biological events. Although BMP4 expression has been well described in the early development of central nervous system (CNS), little information is available for its expression in the adult CNS. We, thus, investigated BMP4 expression in the adult rat CNS using immunohistochemistry. BMP4 is intensely expressed in most neurons and their dendrites. In addition, intense BMP4 expression was also observed in the neuropil of the gray matters where high plasticity is reported, such as the molecular layer of the cerebellum and the superficial layer of the superior colliculus. Furthermore, we found that astrocytes also express BMP4 protein. These data indicate that BMP4 is more widely expressed throughout the adult CNS than previously reported, and its continued abundant expression in the adult brain strongly supports the idea that BMP4 plays pivotal roles also in the adult brain.