Factors associated with optic nerve head blood flow and color tone: a retrospective observational study
Factors associated with optic nerve head blood flow and color tone: a retrospective observational study
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DOI：
10.1007/s00417-015-3247-0
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发表时间：
2016-05-01
影响因子：
2.7
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
--
作者：
Kuroda, Yoshimasa;Uji, Akihito;Yoshimura, Nagahisa
目的探讨视神经乳头（optic nerve head，ONH）血流与色调的关系。我们检查了17名年轻健康受试者的29只眼和26名接受白内障手术的白内障患者的37只眼。使用激光散斑血流图测量血流，并使用公共领域ImageJ软件定量色调。比较白内障手术前后ONH的血流和色调。结果随着年龄的增加（R =-0.437，P < 0.001）和眼轴长度的增加（R =-0.306，P = 0.012），ONH的平均模糊率（MBR）逐渐降低。在年轻受试者中，ONH发红与MBR呈中度正相关（R = 0.376，P = 0.044）;然而，在整个研究人群中未观察到这种相关性（R = 0.066，P = 0.601）。白内障手术后ONH组MBR明显高于手术前（P < 0.001）。术后ONH发红程度较术前明显减轻（P < 0.001）。白内障手术后MBR的增加与视力的提高（R =-0.399，P = 0.014）和ONH红度的减少（R =-0.433，P = 0.01）相关。ONH的红色外观不是循环系统疾病的指标，特别是在老年人中。透镜混浊似乎低估了使用激光散斑血流图的血流动力学定量。
Purpose To investigate the relationship between optic nerve head (ONH) blood flow and color tone.Methods Retrospective observational study conducted between February 2014 and August 2014. We examined 29 eyes of 17 young healthy subjects and 37 eyes of 26 cataract patients undergoing cataract surgery. Blood flow was measured using laser speckle flowgraphy, and color tone was quantified using the public domain ImageJ software. Blood flow and color tone of the ONH before and after cataract surgery were compared. The influence of age, axial length, and color tone on ONH blood flow were also investigated.Results Mean blur rate (MBR) in the ONH decreased with increasing age (R = -0.437, P < 0.001) and axial length (R = -0.306, P = 0.012). In young subjects, ONH redness had a moderate positive correlation with MBR (R = 0.376, P = 0.044); however, this correlation was not observed in the study population as a whole (R = 0.066, P = 0.601). MBR in the ONH was higher after cataract surgery (P < 0.001). Moreover, the ONH redness reduced postoperatively from that preoperatively (P < 0.001). An increase in MBR after cataract surgery correlated with improved visual acuity (R = -0.399, P = 0.014) and decreased redness the of ONH (R = -0.433, P < 0.01).Conclusions Ocular blood flow decreased in older people and in myopic eyes. The reddish appearance of the ONH was not an indicator of a circulatory condition, particularly in older people. Lens opacity appeared to underestimate hemodynamic quantification using laser speckle flowgraphy.