Place Conditioning
Place Conditioning
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DOI：
10.1007/978-1-60761-934-5_6
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Voorhees, Charlene M.
中科院分区：
文献类型：
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作者：
Cunningham, Christopher L.;Groblewski, Peter A.;Voorhees, Charlene M.
位置条件反射是一种刺激-结果学习的形式，通常用于推断精神活性药物的奖励和厌恶作用。这一章主要集中在方法论的问题，出现在实施和解释的地方条件反射研究。的基本程序的描述之后，讨论了几个关键的方法问题，包括隔间配置，设备的偏见，刺激的选择，时间参数（刺激间隔，试验持续时间，试验间隔），实验设计和控制，因变量，和自发活动。然后考虑到方法和解释时出现的问题，使用的地方条件反射程序来研究收购与表达，灭绝，并恢复地方条件反射。本章最后简要讨论了地方条件反射程序的潜在相关性，以了解人类的药物寻求和成瘾。
Place conditioning is a form of stimulus-outcome learning that is commonly used to draw inferences about the rewarding and aversive effects of psychoactive drugs. This chapter focuses primarily on methodological issues that arise in the implementation and interpretation of place-conditioning studies. A description of the basic procedure is followed by a discussion of several key methodological issues, including compartment configuration, apparatus bias, stimulus selection, temporal parameters (interstimulus interval, trial duration, intertrial interval), experimental design and controls, dependent variables, and locomotor activity. Consideration is then given to methodological and interpretative issues that arise when using the place-conditioning procedure to study acquisition versus expression, extinction, and reinstatement of place conditioning. The chapter concludes with a brief discussion of the potential relevance of the place-conditioning procedure for understanding drug seeking and addiction in humans.