Lack of consistent sex differences in D-amphetamine-induced dopamine release measured with [18F]fallypride PET.
Lack of consistent sex differences in D-amphetamine-induced dopamine release measured with [18F]fallypride PET.
复制标题
使用 [18F]fallypride PET 测量的 D-苯丙胺诱导的多巴胺释放缺乏一致的性别差异。
DOI：
10.1007/s00213-018-5083-5
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发表时间：
2019
影响因子：
3.4
通讯作者：
Zald,DavidH
中科院分区：
文献类型：
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作者：
Smith,ChristopherT;Dang,LinhC;Burgess,LeahL;Perkins,ScottF;SanJuan,MDanica;Smith,DarcyK;Cowan,RonaldL;Le,NamT;Kessler,RobertM;Samanez-Larkin,GregoryR;Zald,DavidH
多巴胺能对精神兴奋剂反应的性别差异可能对药物滥用风险和其他涉及多巴胺系统的精神病理学有影响，但人类数据有限且混合。ObjectiveHere，我们试图调查口服苯丙胺后多巴胺释放的性别差异。MethodsWe使用[18F]fallypride正电子发射断层扫描（PET）测量多巴胺D2/3受体可用性的变化（%ΔBPND，多巴胺释放指数）在两个独立的数据集中，共包含39名女性（激素避孕= 18，绝经后= 10，或在月经周期的前10天研究= 11）和37名男性。我们未能一致地检测到广泛的性别差异ind-amphetamine诱导的多巴胺释放。然而，有有限的证据表明，相对于年龄相仿的女性，年轻成年男性的右腹侧纹状体多巴胺释放量更大，但在样本中并没有一致的观察结果。血浆雌二醇与多巴胺的释放，这一措施并没有不同的女性和关闭激素birth control.ConclusionsWhile我们的发现在年轻的成年人从一个数据集的更大%Δ BPND在男性是部分与先前发表的研究性别差异ind-amphetamine诱导的多巴胺释放一致，我们的数据不支持存在一致的广泛的性别差异，这一措施的多巴胺释放。
RationaleSex differences in the dopaminergic response to psychostimulants could have implications for drug abuse risk and other psychopathology involving the dopamine system, but human data are limited and mixed.ObjectivesHere, we sought to investigate sex differences in dopamine release after orald-amphetamine administration.MethodsWe used [18F]fallypride positron emission tomography (PET) to measure the change in dopamine D2/3 receptor availability (%ΔBPND, an index of dopamine release) between placebo andd-amphetamine sessions in two independent datasets containing a total of 39 females (on either hormonal birth controln= 18, postmenopausaln= 10, or studied in the first 10 days of their menstrual cyclen= 11) and 37 males.ResultsUsing both a priori anatomical regions of interest based on previous findings and voxelwise analyses, we failed to consistently detect broad sex differences ind-amphetamine-induced dopamine release. Nevertheless, there was limited evidence for greater right ventral striatal dopamine release in young adult males relative to similarly aged females, but this was not consistently observed across samples. Plasma estradiol did not correlate with dopamine release and this measure did not differ in females on and off hormonal birth control.ConclusionsWhile our finding in young adults from one dataset of greater %ΔBPNDin males is partially consistent with a previously published study on sex differences ind-amphetamine-induced dopamine release, our data do not support the presence of consistent widespread sex differences in this measure of dopamine release.