BARRETTS-ESOPHAGUS - AGE, PREVALENCE, AND EXTENT OF COLUMNAR EPITHELIUM
BARRETTS-ESOPHAGUS - AGE, PREVALENCE, AND EXTENT OF COLUMNAR EPITHELIUM
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DOI：
10.1016/0016-5085(92)91510-b
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发表时间：
1992-10-01
期刊：
影响因子：
29.4
通讯作者：
LOMBOY, CT
中科院分区：
文献类型：
--
作者：
CAMERON, AJ;LOMBOY, CT
Barrett食管的发展是通过1976年至1989年间51311例接受上消化道内窥镜检查的患者的数据来研究的。377例患者食道柱状上皮≥3cm，无癌。巴雷特食管的患病率随着年龄的增长而增加，到70岁时达到平稳期。最大患病率的一半是在40岁时达到的，这是疾病发展的估计中位数年龄。与患病率不同，柱状上皮的平均长度不随年龄增长而增加。21例患者平均随访7.3年，长度无明显变化（平均初始长度8.29±0.85 cm，平均最终长度8.33±0.77 cm）。食管炎时，柱状上皮的长度不增加，无食管炎时，柱状上皮的长度不减少。Barrett食管诊断时的平均年龄为63岁，未患癌的患者平均年龄为64岁，另一组患有腺癌的患者平均年龄为64岁。这些数据与Barrett食管快速进化到全长几乎没有后续变化相一致。巴雷特食管的发展可能比临床发现或发展为食管腺癌的平均年龄早20年以上。
The development of Barrett's esophagus was studied using data from 51,311 patients undergoing upper gastrointestinal endoscopy between 1976 and 1989. Three hundred seventy-seven patients had ≥ 3-cm columnar epithelium in the esophagus and no carcinoma. The prevalence of Barrett's esophagus increased with age to reach a plateau by the seventh decade. Half of the maximum prevalence was reached by age 40 years, the estimated median age of development of the disorder. Unlike prevalence, the mean length of columnar epithelium did not increase with age. No significant change in length was found in 21 patients followed up for a mean of 7.3 years (mean initial length, 8.29 ± 0.85 cm; mean final length, 8.33 ± 0.77 cm). The length of columnar epithelium did not increase in the presence of esophagitis or decrease when esophagitis was absent. Mean age at diagnosis of Barrett's esophagus was 63 years without carcinoma and 64 years in a separate group of patients with adenocarcinoma. The data are consistent with a fairly rapid evolution of Barrett's esophagus to its full length with little subsequent change. Barrett's esophagus may develop more than 20 years before the mean age of clinical recognition or the development of esophageal adenocarcinoma.