Preliminary study of anxiety symptoms, family dysfunction, and the brain-derived neurotrophic factor (BDNF) Val66Met genotype in offspring of parents with bipolar disorder.
Preliminary study of anxiety symptoms, family dysfunction, and the brain-derived neurotrophic factor (BDNF) Val66Met genotype in offspring of parents with bipolar disorder.
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双相情感障碍父母后代焦虑症状、家庭功能障碍和脑源性神经营养因子 (BDNF) Val66Met 基因型的初步研究。
DOI：
10.1016/j.jpsychires.2014.11.013
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发表时间：
2015
影响因子：
4.8
通讯作者：
Singh,ManpreetK
中科院分区：
文献类型：
--
作者：
Park,Min-Hyeon;Chang,KikiD;Hallmayer,Joachim;Howe,MeghanE;Kim,Eunjoo;Hong,SeungChul;Singh,ManpreetK
一些遗传和环境因素使双相情感障碍（BD）父母的年轻后代处于发展情绪和焦虑障碍的高风险中。最近的研究表明，焦虑症状，即使在亚临床水平，已与发展BD的风险增加。脑源性神经营养因子（BDNF）基因与BD和焦虑症的病理生理学有关。我们的目的是探讨BD后代的焦虑是否与BDNF Val 66 Met多态性相关。64只BD子代（平均年龄：13.73（S.D.）男性30例，女性34例; 2.68（M= 23，F= 28）在met等位基因的存在和来自儿童多维焦虑量表（MASC）的分数上进行比较。为了评估家庭功能，我们使用了家庭适应性和凝聚力评估量表（FACES-IV）。Baron & Kenny方法是用于检查变量之间调节效应的统计方法。BD后代表现出更高水平的整体焦虑比HC组。具有瓦尔/瓦尔基因型的BD后代比具有其他基因型的BD后代表现出更高水平的焦虑。在HC组中没有发现显著水平的焦虑或其与BDNF基因型的关联。BD后代组比HC组表现出更多的家庭功能障碍，家庭功能障碍调节了BDNF基因型与焦虑症状之间的关联。这项研究表明，三个因素的潜在相互作用：BD后代，焦虑症状和家庭功能障碍。
Several genetic and environmental factors place youth offspring of parents with bipolar disorder (BD) at high risk for developing mood and anxiety disorders. Recent studies suggest that anxiety symptoms, even at subclinical levels, have been associated with an increased risk for developing BD. The brain-derived neurotrophic factor (BDNF) gene has been implicated in the pathophysiology of both BD and anxiety disorders. We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism. 64 BD offspring (mean age: 13.73 (S.D. 3.45)M= 30,F= 34) and 51 HC (mean age: 13.68 (S.D. 2.68)M= 23,F= 28) were compared on presence of the met allele and on scores from the Multidimensional Anxiety Scale for Children (MASC). To assess family function, we used the Family Adaptability and Cohesion Evaluation Scales (FACES-IV). The Baron & Kenny method was the statistical approach used to examine the moderating effects between variables. BD offspring showed higher levels of overall anxiety than did the HC group. BD offspring with the val/val genotype showed higher levels of anxiety than BD offspring with other genotypes. No significant levels of anxiety or its association with BDNF genotype were found in the HC group. BD offspring group showed significantly more family dysfunction when compared with the HC group and the family dysfunction moderated the association between the BDNF genotype and anxiety symptoms. This study demonstrated the potential interplay of three factors: BD offspring, anxiety symptoms and family dysfunction.