Patients with intractable epilepsy have low melatonin, which increases following seizures
Patients with intractable epilepsy have low melatonin, which increases following seizures
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DOI：
10.1212/wnl.55.11.1746
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发表时间：
2000-12-12
期刊：
影响因子：
9.9
通讯作者：
Zheng, W
中科院分区：
文献类型：
--
作者：
Bazil, CW;Short, D;Zheng, W
用于治疗睡眠障碍的褪黑激素具有抗惊厥特性。作者在基线和癫痫发作后测量了难治性颞叶癫痫患者和对照组的唾液褪黑激素和皮质醇，与对照组相比，癫痫患者的褪黑激素在基线时减少，在癫痫发作后增加了三倍。癫痫发作后皮质醇也增加。难治性癫痫患者的基线褪黑激素水平较低，在癫痫发作后急剧增加。
Melatonin, which is used to treat sleep disorders, has anticonvulsant properties. The authors measured salivary melatonin and cortisol, at baseline and following seizures, in patients with intractable temporal lobe epilepsy and controls, Melatonin was reduced in patients with epilepsy at baseline compared with controls, and increased threefold following seizures. Cortisol also increased following seizures. Patients with intractable epilepsy have low baseline melatonin levels that increase dramatically following seizures.