INTRAUTERINE REPAIR OF EXPERIMENTAL SURGICALLY CREATED DYSRAPHISM
INTRAUTERINE REPAIR OF EXPERIMENTAL SURGICALLY CREATED DYSRAPHISM
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DOI：
10.1227/00006123-199306000-00021
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发表时间：
1993-06-01
期刊：
影响因子：
4.8
通讯作者：
MCLONE, DG
中科院分区：
文献类型：
--
作者：
HEFFEZ, DS;ARYANPUR, J;MCLONE, DG
脊髓脊膜膨出的儿童中所见的瘫痪是由于先天性脊髓发育不良所致。然而，临床和病理学数据表明，瘫痪可能部分是由于神经管暴露于子宫内环境引起的脊髓损伤。这种可能性得到了使用手术制造的闭合不全胎鼠模型获得的实验数据的支持。本文报道了胎鼠和胎猪实验性闭合不全的宫内治疗结果。这些研究证实了我们早期的发现，并表明物理创伤和毒性损伤可能有助于脊髓损伤。
THE PARALYSIS SEEN in children with myelomeningocele has been attributed to congenital myelodysplasia. Clinical and pathological data, however, suggest that the paralysis may be due in part to a spinal cord injury caused by exposure of the neural tube to the intrauterine environment. This possibility has been supported by experimental data obtained using a fetal rat model of surgically created dysraphism. In this paper, we report the results of intrauterine treatment of experimental dysraphism in the fetal rat and the fetal pig. These studies confirm our earlier findings and suggest that both physical trauma and toxic injury may contribute to the spinal cord injury.