Opium use, cigarette smoking, and alcohol consumption in relation to pancreatic cancer
Opium use, cigarette smoking, and alcohol consumption in relation to pancreatic cancer
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DOI：
10.1097/md.0000000000003922
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发表时间：
2016-07-01
期刊：
影响因子：
1.6
通讯作者：
Pourshams, Akram
中科院分区：
文献类型：
--
作者：
Shakeri, Ramin;Kamangar, Farin;Pourshams, Akram
背景和目标：虽然有几项研究表明鸦片是食道癌、胃癌、喉癌、肺癌和膀胱癌的危险因素，但以前没有研究研究过鸦片与胰腺癌的关系。我们的目的是研究鸦片的使用和胰腺癌的风险之间的关系，在伊朗，使用病例对照设计。我们还研究了吸烟和饮酒与胰腺癌的关系，这方面的信息很少，从这个population.Methods：病例和对照组被选中的患者谁被称为4内镜超声中心在德黑兰，伊朗。我们从2011年1月至2015年1月招募了316例组织病理学（均为腺癌）和41例临床诊断的胰腺癌病例，以及328例正常胰腺的对照。结果：调整潜在混杂因素后，鸦片使用（OR 1.91; 95%CI 1.06-3.43）和饮酒（OR 4.16; 95%CI 1.86-9.31）与胰腺癌风险增加显著相关。我们没有发现吸烟与胰腺癌风险之间的关联（OR 0.93; 95%CI 0.62-1.39）。结论：在我们的研究中，鸦片使用和饮酒与胰腺癌风险增加有关，而吸烟则无关。
Background and Aims: Although several studies have suggested opium as a risk factor for cancers of the esophagus, stomach, larynx, lung, and bladder, no previous study has examined the association of opium with pancreatic cancer. We aimed to study the association between opium use and risk of pancreatic cancer in Iran, using a case-control design. We also studied the association of cigarette smoking and alcohol consumption with pancreatic cancer, for which little information was available from this population.Methods: Cases and controls were selected from patients who were referred to 4 endoscopic ultrasound centers in Tehran, Iran. We recruited 316 histopathologically (all adenocarcinoma) and 41 clinically diagnosed incident cases of pancreatic cancer, as well as 328 controls from those with a normal pancreas in enodosonography from January 2011 to January 2015. We used logistic regression models to calculate odds ratios (ORs) and 95% confidence intervals (CIs).Results: After adjustment for potential confounders, opium use (OR 1.91; 95% CI 1.06-3.43) and alcohol consumption (OR 4.16; 95% CI 1.86-9.31) were significantly associated with an increased risk of pancreatic cancer. We did not find an association between ever tobacco smoking and pancreatic cancer risk (OR 0.93; 95% CI 0.62-1.39).Conclusion: In our study, opium use and alcohol consumption were associated with an increased risk of pancreatic cancer, whereas cigarette smoking was not.