Task-dependent modulation of SI physiological responses to targets and distractors.
Task-dependent modulation of SI physiological responses to targets and distractors.
复制标题
SI 对目标和干扰物的生理反应的任务依赖性调节。
DOI：
10.1152/jn.00385.2012
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发表时间：
2013
影响因子：
2.5
通讯作者：
Blake,DavidT
中科院分区：
文献类型：
--
作者：
Spingath,Elsie;Kang,Hyun-Sug;Blake,DavidT
选择性注意实验设计表明，当感觉刺激与任务相关时，初级躯体感觉皮层对刺激的神经反应更强。其他研究使用了没有任务要求的动物进行数据收集。在行为过程中大脑神经反应之间的关系，而动物没有任务要求，仍然没有得到充分的探索。我们训练了两只动物进行几周的体感检测，然后进行几周的体感辨别。从皮层植入物收集响应于物理上相同的刺激的数据，而动物在每个行为会话之前和在该行为会话期间没有任务要求。与无任务条件相比，检测或辨别期间的场电位的傅立叶频谱表明，与体感和运动输入的认知使用的准备和预期相关的体感μ节律受到抑制。检测和区分期间对任务目标的反应比无任务条件下更强。两种情况下的目标诱发反应的振幅归一化时间过程是相似的。诱发反应的任务干扰并没有显着更强的行为比在录音下没有任务的要求。分心物反应的标准化时间过程显示出在反应开始后30-35 ms达到峰值的抑制。这种试验内抑制的选择性与感觉皮层可塑性研究中明显的持久抑制的选择性相同，这表明相同的神经过程可能对两者负责。
Selective attention experimental designs have shown that neural responses to stimuli in primary somatosensory cortex are stronger when the sensory stimuli are task relevant. Other studies have used animals under no task demands for data collection. The relationship between neural responses in the brain during behavior, and while an animal has no task demands, remains underexplored. We trained two animals to perform somatosensory detection for several weeks, followed by somatosensory discrimination for several weeks. Data in response to physically identical stimuli were collected from cortical implants while the animal was under no task demands before each behavioral session and also during that behavioral session. The Fourier spectra of the field potentials during detection or discrimination compared with the no task condition demonstrated suppression of the somatosensory μ-rhythm that is associated with readiness and anticipation of cognitive use of somatosensory and motor inputs. Responses to the task target were stronger during detection and discrimination than in the no task condition. The amplitude normalized time course of the target evoked response was similar in both cases. Evoked responses to the task distractor were not significantly stronger during behavior than in recordings under no task demands. The normalized time course of the distractor responses showed a suppression that peaks 30–35 ms after the onset of the response. The selectivity of this within trial suppression is the same as the selectivity of enduring suppression evident in studies of sensory cortical plasticity, which suggests the same neural process may be responsible for both.