Meiotic Recombination: The Essence of Heredity
Meiotic Recombination: The Essence of Heredity
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DOI：
10.1101/cshperspect.a016618
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发表时间：
2015-12-01
影响因子：
7.2
通讯作者：
Hunter, Neil
中科院分区：
文献类型：
--
作者：
Hunter, Neil
同源重组的研究有其历史根源在减数分裂。在这种情况下，重组作为程序化事件发生，最终形成交叉，这对于准确的染色体分离和创造亲本等位基因的新组合是必不可少的。因此，减数分裂重组是亲本染色体独立分配和遗传连锁的基础。这篇综述强调了减数分裂重组的特点，区分它从体细胞中的重组修复，以及如何减数分裂重组的分子过程是嵌入和相互依赖的染色体结构，特征减数分裂前期。一个更深入的审查介绍了我们的理解，如何交叉和非交叉途径的减数分裂重组的分化和调节。本综述的最后一部分总结了将缺陷重组定义为人类妊娠丢失和先天性疾病的主要原因的研究。
The study of homologous recombination has its historical roots in meiosis. In this context, recombination occurs as a programmed event that culminates in the formation of crossovers, which are essential for accurate chromosome segregation and create new combinations of parental alleles. Thus, meiotic recombination underlies both the independent assortment of parental chromosomes and genetic linkage. This review highlights the features of meiotic recombination that distinguish it from recombinational repair in somatic cells, and how the molecular processes of meiotic recombination are embedded and interdependent with the chromosome structures that characterize meiotic prophase. A more in-depth review presents our understanding of how crossover and noncrossover pathways of meiotic recombination are differentiated and regulated. The final section of this review summarizes the studies that have defined defective recombination as a leading cause of pregnancy loss and congenital disease in humans.
影响因子：
4.5
作者：
Thacker D;Keeney S
通讯作者：
Keeney S