Uterine and placental expression of steroidogenic genes during rodent pregnancy
Uterine and placental expression of steroidogenic genes during rodent pregnancy
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DOI：
10.1016/s0303-7207(01)00713-4
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发表时间：
2002-02-22
影响因子：
4.1
通讯作者：
Orly, J
中科院分区：
文献类型：
--
作者：
Ben-Zimra, M;Koler, M;Orly, J
哺乳动物妊娠期间类固醇生成的个体发生和功能作用尚不清楚。本文综述了小鼠妊娠期间子宫内控制孕酮合成的关键激素生成基因的时空表达的最新发现。我们已经证明，胆固醇侧链切割细胞色素P450 （P450sec）和一种新发现的小鼠3 β -羟基类固醇脱氢酶异构酶VI型（3betaHSD VI）异构体的表达发生在着床诱导的子宫壁脱体化过程中。这种意想不到的母体蜕膜中酶的早期表达在妊娠中期终止，此时在胎盘期胚胎外巨细胞中再次出现类固醇生成能力。巨细胞表达另一种在肾上腺和性腺中合成类固醇激素不可或缺的蛋白质。类固醇急性调节蛋白。不像人类的胎盘。在妊娠后半期成熟小鼠胎盘细胞中不表达类固醇基因。最后。我们的研究表明，P450scc的转录调控是由一种非SF-1蛋白介导的，该蛋白在胚胎外细胞中替代SF-1功能。集体。目前的研究结果表明，在怀孕的早期阶段。母体蜕膜和胚腔周围滋养层的局部孕酮合成对成功着床和/或维持妊娠非常重要。我们认为，孕酮的局部产生在母胎界面起免疫抑制剂的作用，导致胎儿异体移植物的排斥反应。(C) 2002年由爱思唯尔科学爱尔兰有限公司出版
The ontogeny and functional role of steroidogenesis during mammalian gestation is poorly understood. This review provides a summary of our recent findings on the spatio-temporal expression of key steroidogenic genes controlling progesterone synthesis in the uterus during mouse pregnancy. We have shown that onset of cholesterol side chain cleavage cytochrome P450 (P450sec) and a newly identified isoform of murine 3beta-hydroxysteroid dehydrogenase isomerase type VI (3betaHSD VI) expression Occurs upon decidualization of the uterine wall induced by implantation. This unexpected early expression of the enzymes in the maternal decidua is terminated at mid-pregnancy when the steroidogenic ability reappears in the extraembryonic giant cells at the time of placentation. The giant cells express another protein indispensable for steroid hormone synthesis in the adrenal and gonads. Steroidogenic Acute Regulatory (StAR) protein. Unlike the human placenta. the steroidogenic genes Lire not expressed in the cells of the mature mouse placenta during the second half of gestation. Finally. our studies suggest that transcriptional regulation of P450scc is mediated by a non-SF-1 protein that Substitutes SF-1 functions in the extraembryonic cells. Collectively. the results of the present study suggest that, during early phases of pregnancy. local progesterone synthesis in the maternal decidua and the trophoblast layers surrounding the embryonal cavity is important for successful implantation and/or maintenance of pregnancy. We propose that the local production of' progesterone acts as an immunosuppressant at the maternofetal interface presenting the rejection of the fetal allograft. (C) 2002 Published by Elsevier Science Ireland Ltd.