Clinicopathological features and prognostic factors of Japanese patients with "peripheral T-cell lymphoma, unspecified" diagnosed according to the WHO classification
Clinicopathological features and prognostic factors of Japanese patients with "peripheral T-cell lymphoma, unspecified" diagnosed according to the WHO classification
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DOI：
10.1016/j.leukres.2004.04.016
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发表时间：
2004-12-01
影响因子：
2.7
通讯作者：
Nagasawa, T
中科院分区：
文献类型：
--
作者：
Kojima, H;Hasegawa, Y;Nagasawa, T
本文回顾了36例患者的临床病理特征，男性：58.3%；中位年龄：68岁，按WHO标准诊断为“外周T细胞淋巴瘤，未指明”。大多数(69.4%)为IV期疾病，常累及骨髓、脾、肝和皮肤。根据IPI，72.2%的人被归类为高风险或高中风险组。31例以CHOP为基础的化疗中，CR12例，PR 10例。1年和2年总生存率分别为60.6%和25.0%。运动状态、血清乳酸脱氢酶和B症状是显著的预后因素。与细胞毒性T细胞淋巴瘤相对应的CD_4~+/CD_8~+患者的存活率明显低于CD_4~+/CD_8~-患者。(C)2004爱思唯尔有限公司。保留所有权利。
Clinicopathological features of 36 patients, male: 58.3%; median: 68 years, with "peripheral T-cell lymphoma, unspecified" diagnosed by the WHO criteria were reviewed. Majority (69.4%) had stage IV disease with frequent involvements into bone marrow, spleen, liver, and skin. According to the IPI, 72.2% were categorized as high or high-intermediate risk group. CR and PR were achieved in 12 and 10 out of 31 patients treated by CHOP-based chemotherapy, respectively. One- and two-year overall survivals were 60.6 and 25.0%, respectively. Performance status, serum LDH, and B symptom were significant prognostic factors. Survival of CD4-/CD8+ cases, corresponding to cytotoxic T-cell lymphoma, was significantly worse than that of CD4+/CD8-. (C) 2004 Elsevier Ltd. All rights reserved.