A PRELIMINARY STUDY ON THE INTERFERON-α TREATMENT FOR XEROSTOMIA OF SJÖGREN'S SYNDROME
A PRELIMINARY STUDY ON THE INTERFERON-α TREATMENT FOR XEROSTOMIA OF SJÖGREN'S SYNDROME
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干扰素-α治疗干燥综合征口干症的初步研究
DOI：
10.1093/rheumatology/32.1.52
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发表时间：
1993
期刊：
影响因子：
5.5
通讯作者：
K. Shiozawa
中科院分区：
文献类型：
--
作者：
S. Shiozawa;I. Morimoto;Yoshiya Tanaka;K. Shiozawa
我们每周一次肌肉注射1 × 10（6）单位的干扰素α，研究干扰素α对干燥综合征口干症的治疗效果。通过Saxon试验定量唾液产生。在干扰素α给药前的3个月期间，每月测量一次的唾液分泌变化在+/- 0.30 g/2 min内。在干扰素α给药后，6例患者的唾液分泌增加至大于0.30 g/2 min，配对t检验显示增加具有统计学意义（P = 0.002）。结果表明，这种药物在增加原发性干燥综合征患者的唾液产生方面具有有益作用。
We studied the therapeutic effect of interferon-alpha on the xerostomia of Sjogren's syndrome by injecting 1 x 10(6) units of interferon-alpha intramuscularly once weekly. Saliva production was quantitated by the Saxon test. Variation of saliva production measured at monthly intervals during the 3-month period prior to administration of interferon-alpha was within +/- 0.30 g/2 min. After administration of interferon-alpha, saliva production increased to greater than 0.30 g/2 min in six patients, and the increase was statistically significant by the paired t-test (P = 0.002). The result suggests a beneficial effect of this agent in increasing the saliva production of patients with primary Sjogren's syndrome.