FOXO3a knockdown promotes radioresistance in nasopharyngeal carcinoma by inducing epithelial-mesenchymal transition and the Wnt/β-catenin signaling pathway
FOXO3a knockdown promotes radioresistance in nasopharyngeal carcinoma by inducing epithelial-mesenchymal transition and the Wnt/β-catenin signaling pathway
复制标题
FOXO3a敲低通过诱导上皮间质转化和Wnt/β-catenin信号通路促进鼻咽癌的放射抗性
DOI：
10.1016/j.canlet.2019.04.019
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发表时间：
2019-01-01
期刊：
影响因子：
9.7
通讯作者：
Hu, Guoqing
中科院分区：
文献类型：
--
作者：
Luo, Min;Wu, Cheng;Hu, Guoqing
Mutations in the forkhead box O 3a (FOXO3a) gene are closely related to the progression of several types of cancers. However, few studies explore the relationship between FOXO3a and nasopharyngeal carcinoma (NPC). Our findings demonstrate that silencing FOXO3a promotes tumor radioresistance of NPC in vitro and in vivo through inducing EMT and activating Wnt/beta-catenin signal pathway. These data establish that FOXO3a can be a novel and reliable NPC marker and a potential therapeutic target against NPC.
