Antimullerian hormone serum levels: a putative marker for ovarian aging
Antimullerian hormone serum levels: a putative marker for ovarian aging
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DOI：
10.1016/s0015-0282(01)02993-4
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发表时间：
2002-02-01
影响因子：
6.7
通讯作者：
Fauser, BCJM
中科院分区：
文献类型：
--
作者：
de Vet, A;Laven, JSE;Fauser, BCJM
目的：探讨血清抗苗勒管激素浓度是否可作为卵巢衰老的标志。设计：纵向观察研究。单位：学术研究中心。患者：41名排卵正常的绝经前妇女和13名健康的绝经后妇女。主要观察指标：血清抗苗勒管激素（间隔2.6 +/- 1.7年两次评估）、卵泡刺激素（FSH）、抑制素B （inhibin B）、雌二醇（estradiol）浓度及超声检查卵巢卵泡数量。结果：随着时间的推移，抗苗勒管激素的浓度显著下降（第一次访问时的中位数为2.1马克/升[范围，0.1-7.4马克/升]，第二次访问时为1.3马克/升[范围，0.0-5.0马克/升]），而窦泡的数量、促卵泡刺激素和抑制素B的水平没有变化。在第1次和第2次就诊时，抗苗勒管激素浓度与年龄相关(r = - 0.40， P= 0.01和r = - 0.57， P
Objective: To investigate whether serum concentrations of antimullerian hormone may be used as a marker for ovarian aging.Design: Longitudinal observational study.Setting: Academic research center.Patient(s): Forty-one normo-ovulatory premenopausal women and 13 healthy postmenopausal women.Main Outcome Measure(s): Concentrations of serum antimullerian hormone (assessed on two occasions 2.6 +/- 1.7 years apart), FSH, inhibin B, and estradiol and number of ovarian follicles on ultrasonography.Result(s): Concentrations of antimullerian hormone decreased significantly over time (median value, 2.1 mug/L [range, 0.1-7.4 mug/L] at visit 1 vs. 1.3 mug/L [range, 0.0-5.0 mug/L] at visit 2), whereas the number of antral follicles and levels of FSH and inhibin B did not change. During visits 1 and 2, concentrations of antimullerian hormone correlated with age (r = -.40, P=.01 and r = -.57, P