Young adult female fragile X premutation carriers show age- and genetically-modulated cognitive impairments.
Young adult female fragile X premutation carriers show age- and genetically-modulated cognitive impairments.
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DOI：
10.1016/j.bandc.2011.01.001
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发表时间：
2011-04
影响因子：
2.5
通讯作者：
Simon, Tony J.
中科院分区：
文献类型：
--
作者：
Goodrich-Hunsaker, Naomi J.;Wong, Ling M.;McLennan, Yingratana;Srivastava, Siddharth;Tassone, Flora;Harvey, Danielle;Rivera, Susan M.;Simon, Tony J.
The high frequency of the fragile X premutation in the general population and its emerging neurocognitive implications highlight the need to investigate the effects of the premutation on lifespan cognitive development. Until recently, cognitive function in fragile X premutation carriers (fXPCs) was presumed to be unaffected by the mutation. Here we show that young adult female fXPCs show subtle, yet significant, age- and FMR1 gene mutation-modulated cognitive impairments as tested by a quantitative magnitude comparison task. Our results begin to define the neurocognitive endophenotype associated with the premutation in adults, who are at risk for developing a neurodegenerative disorder associated with the fragile X premutation. Results from the present study may potentially be applied toward the design of early interventions wherein we might be able to target premutation carriers most at risk for degeneration for preventive treatment.
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影响因子：
2.5
作者：
Keri, Szabolcs;Benedek, Gyoergy
通讯作者：
Benedek, Gyoergy
DOI：
10.4088/jcp.08m04476
发表时间：
2009-06
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Bourgeois JA;Coffey SM;Rivera SM;Hessl D;Gane LW;Tassone F;Greco C;Finucane B;Nelson L;Berry-Kravis E;Grigsby J;Hagerman PJ;Hagerman RJ
通讯作者：
Hagerman RJ
影响因子：
9.9
作者：
Leehey, M. A.;Berry-Kravis, E.;Hagerman, P. J.
通讯作者：
Hagerman, P. J.
影响因子：
64.5
作者：
FU, YH;KUHL, DPA;CASKEY, CT
通讯作者：
CASKEY, CT
影响因子：
2.9
作者：
Farzin, Faraz;Rivera, Susan M.
通讯作者：
Rivera, Susan M.